2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(4-Methoxy-benzyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-tetrahydro-pyran | 669556-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(4-Methoxy-benzyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-tetrahydro-pyran
• CAS: 669556-44-9
• 化学式: C₃₁H₅₄O₁₂
• 分子量: 618.763
• InChiKey: AWXUDFGZUSCKPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.89
• 重原子数：
  43.0
• 可旋转键数：
  31.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  110.76
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(4-Methoxy-benzyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-tetrahydro-pyran 在 ammonium cerium(IV) nitrate 作用下， 以 水 、 乙腈 为溶剂， 反应 4.0h， 以83%的产率得到羟基-九聚乙二醇-四氢吡喃醚
  参考文献：
  名称：

  Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains

  摘要：

  A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2CH2)(n)Y (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.

  DOI：

  10.1021/jo035042v
• 作为产物：
  描述：

  四氢吡喃醚-三聚乙二醇 在 吡啶 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(4-Methoxy-benzyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-tetrahydro-pyran
  参考文献：
  名称：

  Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains

  摘要：

  A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2CH2)(n)Y (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.

  DOI：

  10.1021/jo035042v

文献信息

• Multigram Synthesis of Well-Defined Extended Bifunctional Polyethylene Glycol (PEG) Chains
  作者：François A. Loiseau、King Kuok (Mimi) Hii、Alison M. Hill

  DOI：10.1021/jo035042v

  日期：2004.2.1

  A series of novel, well-defined, unsymmetrical poly(ethylene glycol) chains of the type X(OCH2CH2)(n)Y (where X = protecting group; Y = nucleofuge or a different protecting group; n = 3, 6, 9, 12, 15, 18, and 24) were prepared in high yields by applying orthogonal protecting groups. The purity of the compounds was fully verified by elemental and high-resolution mass spectrometry analyses.