2,4-dibromo-1-tert-butyl-benzene | 6683-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dibromo-1-tert-butyl-benzene
• 英文别名: 2,4-Dibrom-1-tert-butyl-benzol；2,4-Dibrom-1-t-butylbenzol；2,4-Dibromo-1-tert-butylbenzene
• CAS: 6683-76-7
• 化学式: C₁₀H₁₂Br₂
• 分子量: 292.013
• InChiKey: UUGZDEUBOMNDDB-UHFFFAOYSA-N

物化性质

• 沸点：
  112-116 °C(Press: 4 Torr)
• 密度：
  1.4642 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,4-dibromo-1-tert-butyl-benzene 在 硝酸 作用下， 生成 2,4-二溴-1-叔-丁基-3,5-二硝基-苯
  参考文献：
  名称：

  NITRO MUSKS. I. ISOMERS, HOMOLOGS, AND ANALOGS OF MUSK AMBRETTE

  摘要：

  DOI：

  10.1021/jo01144a011
• 作为产物：
  描述：

  4-bromo-1-tert-butyl-2-nitro-benzene 在 盐酸 、 铁粉 作用下， 生成 2,4-dibromo-1-tert-butyl-benzene
  参考文献：
  名称：

  NITRO MUSKS. I. ISOMERS, HOMOLOGS, AND ANALOGS OF MUSK AMBRETTE

  摘要：

  DOI：

  10.1021/jo01144a011

文献信息

• PYRAZOLYL PYRIMIDINAMINE COMPOUND AND APPLICATION THEREOF
  申请人：SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.

  公开号：US20160332991A1

  公开（公告）日：2016-11-17

  Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by Plutella xylostella , armyworm, Myzus persicae, Tetranychus cinnabarinus etc.

  本发明揭示了具有如下式所示结构的吡唑基嘧啶胺化合物：每个取代基的定义可在说明书中看到。本发明的化合物具有广谱的杀菌、杀虫和杀螨活性，并且对黄瓜霜霉病、小麦白粉病、玉米锈病、黄瓜炭疽病等病害具有良好的控制效果，特别对黄瓜霜霉病、小麦白粉病和黄瓜炭疽病有更好的控制效果。本发明的化合物还表现出良好的杀虫活性，其中部分化合物在非常低剂量下对由小菜蛾、军虫、桃蚜、细毛螨等引起的疾病具有出色的控制效果。
• Substituted Pyrazole Compounds Containing Pyrimidine and Preparation Method and Use Thereof
  申请人：Shenyang Sinochem Agrochemicals R&D Co., Ltd.

  公开号：US20180141961A1

  公开（公告）日：2018-05-24

  Disclosed are substituted pyrazole compounds containing pyrimidinyl as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a good spectrum of bactericidal, insecticidal and acaricidal activity,and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, rice blast, cucumber anthracnosis and the like. The compounds of present invention also show good insecticidal activity.

  本公开的是含有嘧啶基团的取代吡唑化合物，其化学式如下所示：各个取代基的定义可在说明中看到。本发明的化合物具有良好的杀菌、杀虫和杀螨活性，并对黄瓜霜霉病、小麦白粉病、玉米锈病、稻瘟病、黄瓜炭疽病等具有良好的防治效果。本发明的化合物还表现出良好的杀虫活性。
• LIVER DELIVERY-BASED ANTIVIRAL PRECURSOR DRUG NUCLEOSIDE CYCLOPHOSPHATE COMPOUND AND USE THEREOF
  申请人：Zhejiang Paloalto Pharmaceutical Technology Co Ltd

  公开号：EP3476854A1

  公开（公告）日：2019-05-01

  Disclosed are a liver specific delivery (LSD)-based antiviral prodrug nucleoside cyclophosphate compound and uses thereof, and in particular, provided are a compound of formula (II), and an isomer, a pharmaceutically acceptable salt, a hydrate and a solvate thereof, and the corresponding pharmaceutical composition. The present invention also provides uses of the present compounds, alone or in combination with other antiviral drugs, in the treatment of the diseases caused by hepatitis B virus (HBV), hepatitis D virus (HDV) and human immunodeficiency virus (HIV).

  本发明公开了一种基于肝脏特异性递送（LSD）的抗病毒原药核苷环磷酸酯化合物及其用途，特别是提供了一种式（II）化合物及其异构体、药学上可接受的盐、水合物和溶液，以及相应的药物组合物。本发明还提供了本发明化合物单独或与其他抗病毒药物联合用于治疗乙型肝炎病毒（HBV）、丁型肝炎病毒（HDV）和人类免疫缺陷病毒（HIV）引起的疾病的用途。
• Baas,J.M.A.; Wepster,B.M., Recueil des Travaux Chimiques des Pays-Bas, 1966, vol. 85, p. 457 - 466
  作者：Baas,J.M.A.、Wepster,B.M.

  DOI：——

  日期：——
• ANTIVIRAL PRECURSOR DRUG NUCLEOSIDE CYCLOPHOSPHATE COMPOUND AND USE THEREOF
  申请人：Zhejiang Paloalto Pharmaceutical Technology Co Ltd

  公开号：EP3476854B1

  公开（公告）日：2021-05-12