(Z,Z,Z)-7,10,13-hexadecatrienoic acid methyl ester | 77388-16-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z,Z,Z)-7,10,13-hexadecatrienoic acid methyl ester
• 英文别名: (7Z,10Z,13Z)-hexadecatrienoic acid methyl ester；methyl (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate
• CAS: 77388-16-0
• 化学式: C₁₇H₂₈O₂
• 分子量: 264.408
• InChiKey: DUOCBVNCDAEWTB-YSTUJMKBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2S)-1-O-(7Z,10Z,13Z)-hexadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O-β-D-galactopyranosyl-sn-glycerol 在 boric acid-borax buffer 、 Lipase type XI 、 Triton X-100 作用下， 反应 1.0h， 生成 (Z,Z,Z)-7,10,13-hexadecatrienoic acid methyl ester
  参考文献：
  名称：

  Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris

  摘要：

  Two new monogalactosyl diacylglycerols were isolated from the freshwater green alga, Chlorella vulgaris, as anti-tumour promoters, together with three monogalactosyl diacylglycerols and two digalactosyl diacylglycerols. The new monogalactosyl diacylglycerol containing (7Z,10Z)-hexadecadienoic acid showed a more potent inhibitory effect toward tumour promotion than the other glycerolipids isolated.

  DOI：

  10.1016/0031-9422(95)00458-j

文献信息

• [EN] ASCORBATE ESTERS OF OMEGA-3 FATTY ACIDS<br/>[FR] ESTERS D'ASCORBATE D'ACIDES GRAS OMÉGA 3
  申请人：JIVA PHARMA INC

  公开号：WO2014134053A1

  公开（公告）日：2014-09-04

  The present invention provides ascorbate esters of omega-3 fatty acids as their pharmaceutically-acceptable salts and pharmaceutically- acceptable formulations for use as dietary supplements with enhanced antioxidant properties, in improving the effectiveness of other drugs and in treatment of hypertriglyceridemia, hypercholestolemia, diabetes, psychiatric and neurological disorders, attention deficit and hyperactivity disorder, and as cosmeceuticals.

  本发明提供了抗坏血酸酯化的ω-3脂肪酸及其药学上可接受的盐和制剂，用作具有增强抗氧化性能的膳食补充剂，在提高其他药物的有效性以及治疗高三酰甘油血症、高胆固醇血症、糖尿病、精神和神经障碍、注意力缺陷和多动症以及作为化妆品成分。
• Detection and identification of complex oxylipins in meadow buttercup (Ranunculus acris) leaves
  作者：Ivan R. Chechetkin、Alexander S. Blufard、Andrey Y. Yarin、Evgenia O. Fedina、Bulat I. Khairutdinov、Alexander N. Grechkin

  DOI：10.1016/j.phytochem.2018.10.030

  日期：2019.1

  Screening of linolipins, i.e. galactolipids containing esterified residues of divinyl ether oxylipins, in the leaves of several higher plants revealed the presence of these complex oxylipins in the meadow buttercup leaves. The rapid accumulation of linolipins occurred in the injured leaves of meadow buttercup, while intact leaves possessed no linolipins. These oxylipins were isolated from the injured leaves, separated and purified by HPLC. The structural analyses of linolipins by UV, mass-spectroscopy and NMR spectroscopy resulted in the identification of eight molecular species. Three of them were identical to linolipins B-D found earlier in the leaves of flax (Linum usitatissimum L.). Other molecular species were identified as 1-O-(omega 5Z)-etherolenoyl-2-O-dinor-(omega 5Z)-etherolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol, 1-O-(omega 5Z)-etherolenoyl-2-O-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-beta-D-galactopyranosyl-sn-glycerol, 1-O-(omega 5Z)-etherolenoyl-2-O-(7Z, 10Z)-hexadecadienoyl-3-O-beta-D-galactopyranosyl-sn-glycerol, 1-0-(omega 5Z)-etherolenoyl-2-O-alpha-linolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol, and 1-O-(omega 5Z)-etherolenoyl-2-O-palmitoyl-3-O-(alpha-galactopyranosyl-1-6-beta-D-galactopyranosyl)-sn-glycerol. The trivial names "linolipins E, F, G, H and I," respectively, have been ascribed to these novel complex oxylipins.
• Ascorbate Esters of Omega-3 Fatty Acids and Their Formulations and Uses
  申请人：JIVA PHARMA, INC.

  公开号：US20150374660A1

  公开（公告）日：2015-12-31

  The present invention provides ascorbate esters of omega-3 fatty acids as their pharmaceutically-acceptable salts and pharmaceutically-acceptable formulations for use as dietary supplements with enhanced antioxidant properties, in improving the effectiveness of other drugs and in treatment of hypertriglyceridemia, hypercholestolemia, diabetes, psychiatric and neurological disorders, attention deficit and hyperactivity disorder, and as cosmeceuticals.
• Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris
  作者：Takashi Morimoto、Akito Nagatsu、Nobutoshi Murakami、Jinsaku Sakakibara、Harukuni Tokuda、Hoyoku Nishino、Akio Iwashima

  DOI：10.1016/0031-9422(95)00458-j

  日期：1995.11

  Two new monogalactosyl diacylglycerols were isolated from the freshwater green alga, Chlorella vulgaris, as anti-tumour promoters, together with three monogalactosyl diacylglycerols and two digalactosyl diacylglycerols. The new monogalactosyl diacylglycerol containing (7Z,10Z)-hexadecadienoic acid showed a more potent inhibitory effect toward tumour promotion than the other glycerolipids isolated.