L-norleucine ethyl ester | 22628-26-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-norleucine ethyl ester
• 英文别名: L-2-Amino-capronsaeure-aethylester；L-Norleucin-aethylester；d-α-Amino-n-capronsaeure-aethylester；L-Norleucine, ethyl ester；ethyl (2S)-2-aminohexanoate
• CAS: 22628-26-8
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: NOLURLQNLRYBJS-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  L-norleucine ethyl ester 在 盐酸 、 乙酰氯 作用下， 以 水 为溶剂， 反应 2.33h， 生成 n-propyl (2S)-2-trifluoroacetamidohexanoate
  参考文献：
  名称：

  Enantioselective systheses of α-amino acids from 10-sulfonamido-isobornyl esters and di-t-butyl azodicarboxylate

  摘要：

  DOI：

  10.1016/s0040-4020(01)86059-2
• 作为产物：
  描述：

  [(1S,2R)-1-(dicyclohexylsulfamoylmethyl)-7,7-dimethyl-2-bicyclo[2.2.1]heptanyl] (2S)-2-aminohexanoate 生成 L-norleucine ethyl ester
  参考文献：
  名称：

  OPPOLZER, WOLFGANG;MORETTI, ROBERT, TETRAHEDRON, 44,(1988) N 17, C. 5541-5552

  摘要：

  DOI：

文献信息

• Design and synthesis of a s-triazene based asymmetric organocatalyst and its application in enantioselective alkylation
  作者：Shrawan K. Mangawa、Ashawani K. Singh、Satish K. Awasthi

  DOI：10.1039/c5ra11209e

  日期：——

  A very efficient chiral organocatalyst was prepared from the readily available cyanuric chloride.

  一个非常高效的手性有机催化剂是从易得的三聚氯氰酸氯制备的。
• Collagen-like peptoid residue-containing structures
  申请人：The Regents of the University of California

  公开号：US06096710A1

  公开（公告）日：2000-08-01

  Synthetic collagen in triple helical conformation and comprising amino acid chains of repeating trimers of highly populated collagen sequences as well as those sequences wherein the proline or hydroxyproline residue is replaced with a peptoid residue. The invention includes methods of preparing synthetic collagen structures having the triple helix conformation present in collagen from collagen-type polypeptides and poly(peptide-peptoid residue) chains by means of a helix-inducing template.

  合成胶原蛋白是以三股螺旋构象为基础，包含高度重复胶原蛋白序列的氨基酸链和那些脯氨酸或羟脯氨酸残基被肽酰氨基酸残基所替代的序列。该发明包括通过螺旋诱导模板的方式，从胶原型多肽和聚（肽-肽酰氨基酸残基）链中制备具有胶原蛋白三股螺旋构象的合成胶原蛋白结构的方法。
• Template-assisted triple helical collagen-like structures
  申请人：The Regents of the University of California

  公开号：US06329506B1

  公开（公告）日：2001-12-11

  Synthetic collagen in triple helical conformation and comprising amino acid chains of repeating trimers of highly populated collagen sequences as well as those sequences wherein the proline or hydroxyproline residue is replaced with a peptoid residue. The invention includes methods of preparing synthetic collagen structures having the triple helix conformation present in collagen from collagen-type polypeptides and poly(peptide-peptoid residue) chains by means of a helix-inducing template.

  该文本的中文翻译如下：合成三股螺旋构型的胶原蛋白，包括高度重复胶原蛋白序列的氨基酸链三聚体以及丙氨酸或羟脯氨酸残基被肽酰氨基酸残基替换的序列。该发明包括通过螺旋诱导模板的方式，从胶原蛋白型多肽和聚（肽-肽酰氨基酸残基）链中制备具有胶原蛋白三股螺旋构象的合成胶原结构的方法。
• 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Genentech, Inc.

  公开号：US20160237086A1

  公开（公告）日：2016-08-18

  Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.

  本文描述了化学式(00A)的化合物以及作为Janus激酶抑制剂的使用方法。
• Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives
  作者：James L. Stanton、Jeffrey W. H. Watthey、Mahesh N. Desai、Barbara M. Finn、Joseph E. Babiarz、Hollis C. Tomaselli

  DOI：10.1021/jm00149a010

  日期：1985.11

  The preparation of a series of 3-amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-acetic acid derivatives 5a-y by reductive amination of 2,3,4,5-tetrahydro-1H-1-benzazepine-2,3-dione (7) with L-amino acid derivatives is described. The compounds were tested for inhibition of angiotensin converting enzyme. The structure-activity profile of the series is discussed. Compound 5a was especially potent when tested in dogs for inhibition of angiotensin I pressor response, having an ID50 = 0.07 mg/kg po.