3,6-二甲基-2,5-吗啉二酮 | 118363-62-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3,6-二甲基-2,5-吗啉二酮
• 英文名称: 3,6-dimethyl-2,5-morpholinedione
• 英文别名: 3,6-Dimethylmorpholine-2,5-dione
• CAS: 118363-62-5
• 化学式: C₆H₉NO₃
• mdl: MFCD18812551
• 分子量: 143.142
• InChiKey: VVCGOQDXURYHJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(2-溴丙酰氨基)丙酸 在 碳酸氢钠 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 24.0h， 以40%的产率得到3,6-二甲基-2,5-吗啉二酮
  参考文献：
  名称：

  Biodegradable bio-absorbable material for clinical practice and method for producing the same

  摘要：

  生物可吸收聚合物（如血管支架和缝线）作为临床实践材料，几乎具有明确的动态特性，如拉伸强度和吸收降解速率。因此，当这些动态特性提高时，生物可吸收聚合物变得脆弱，降解速率变慢。当降解速率提高时，动态特性会受到损害。不利的是，这种生物可吸收聚合物的用途和使用场所有限。因此，通过将生物可吸收聚合物与环状依赖肽共聚合，形成环开放和共聚合依赖肽的共聚物，可以根据依赖肽的含量调整所得到的共聚物的动态特性和降解速率。

  公开号：

  US20050163822A1

文献信息

• Process for the preparation of 3-, 6-substituted 2,5-morpholinediones
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US05466801A1

  公开（公告）日：1995-11-14

  A process for the preparation of 3- and/or 6-substituted 2,5-morpholinediones is disclosed. Such morpholinediones are useful as precursors for the preparation of depsipeptide polymers and copolymers.

  公开了一种制备3-和/或6-取代的2,5-吗啉二酮的方法。这些吗啉二酮可用作合成依赖肽聚合物和共聚物的前体。
• BIODEGRADABLE AND BIORESORBABLE MATERIAL FOR MEDICAL USE
  申请人：Goodman Co., Ltd.

  公开号：EP1832302A1

  公开（公告）日：2007-09-12

  Disclosed is a biodegradable and bioresorbable material for medical use which has excellent degradability, heat resistance and mechanical resistance. The biodegradable and bioresorbable material for medical use comprises a polymer blend of a type A polymer and a type B polymer having the following formulae, respectively: type A polymer: type B polymer: wherein each of X1 and X2 is 0 to 50 mol%; each of Y1 and Y2 is 0 to 50 mol%; each of Z1 and Z2 is 50 to 100 mol%; each of m1 and m2 is an integer of 3 to 8; R1 and R3 independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R1' and R3' independently represent an alkyl group having 1 to 2 carbon atoms; and R2, R2', R4 and R4' independently represent an alkyl group having 1 to 4 carbon atoms, provided that both of X1 and X2 should not be 0 mol%.

  本发明公开了一种生物可降解和生物可吸收医用材料，该材料具有优异的降解性、耐热性和机械耐受性。该生物可降解和生物可吸收医用材料由 A 型聚合物和 B 型聚合物的聚合物混合物组成，它们分别具有以下式子： A 型聚合物： B 型聚合物：其中 X1 和 X2 各占 0 至 50 摩尔%；Y1 和 Y2 各占 0 至 50 摩尔%；Z1 和 Z2 各占 50 至 100 摩尔%；m1 和 m2 各占 3 至 8 的整数；R1 和 R3 独立地代表氢原子或具有 1 至 4 个碳原子的烷基；R1'和 R3'独立地代表具有 1 至 2 个碳原子的烷基；以及 R2、R2'、R4 和 R4'独立地代表具有 1 至 4 个碳原子的烷基，条件是 X1 和 X2 均不得为 0 摩尔%。
• METHOD OF ADJUSTABLE AND CONTROLLABLE RING-OPENING POLYMERIZATION OF CYCLIC COMPOUNDS BY CATALYSIS OF CARBENE DERIVATIVES
  申请人：Nanjing University of Technology

  公开号：EP2327736A1

  公开（公告）日：2011-06-01

  A method of adjustable and controllable ring-opening polymerization of cyclic compounds by catalysis of carbene derivatives. The carbene derivatives are carbene-carbon dioxide adducts, which are represented by the formula below, wherein the dashed line represents an optional double bond; X1 is selected from S or N; X2 is selected from C or N; R1 and R2 are the same or not, selected from hydrogen, alkyl with 1 to 10 carbon atoms, alkyl with 1 to 10 carbon atoms and substituted by one or more of the group of halogen, hydroxyl, phenyl and cyano group, cycloalkyl with 3 to 6 carbon atoms, halogen, adamantyl, phenyl and substituted phenyl; R3 and R4 are the same or not, selected from hydrogen, halogen, cyano, hydroxyl, phenyl, substituted phenyl, alkyl with 1 to 4 carbon atoms and alkyl with 1 to 4 carbon atoms and substituted by one or more of the group of halogen, hydroxyl, phenyl and cyano group; or R3 and R4 constitute cycloalkyl or cycloalkenyl with 3 to 8 carbon atoms, or R3 and R4 constitute benzene ring, or R2 and R3 constitute unsubstituted five- or six-membered N-heterocyclic ring.

  一种通过碳烯衍生物催化环状化合物开环聚合的可调可控方法。碳烯衍生物是碳烯-二氧化碳加合物，由下式表示，其中虚线代表任选双键；X1 选自 S 或 N；X2 选自 C 或 N；R1 和 R2 相同或不相同，选自氢、1 至 10 个碳原子的烷基、1 至 10 个碳原子并被卤素、羟基、苯基和氰基中的一个或多个基团取代的烷基、3 至 6 个碳原子的环烷基、卤素、金刚烷基、苯基和取代苯基；R3 和 R4 相同或不相同，选自氢、卤素、氰基、羟基、苯基、取代苯基、具有 1 至 4 个碳原子的烷基和具有 1 至 4 个碳原子并被一个或多个卤素、羟基、苯基和氰基取代的烷基；或 R3 和 R4 构成具有 3 至 8 个碳原子的环烷基或环烯基，或 R3 和 R4 构成苯环，或 R2 和 R3 构成未取代的五元或六元 N-杂环。
• Bioresorbable and biocompatible thermoplastic elastomer having a shape memory, particularly for biomedical applications and a process for their preparation
  申请人：Centrum Materialów Polimerowych i Weglowych PAN

  公开号：EP2647656A2

  公开（公告）日：2013-10-09

  Bioresorbable, fully biocompatible thermoplastics, especially amorphous, which are aliphatic copolyesters or aliphatic poly(ester-co-carbonate) or poly(ester-co-amide), and poly(ester-co-carbonate-co-amide) or poly(amide-co-carbonate), which exhibit elastic properties at temperatures a little higher than the temperature of the human body in the range of 38 - 45°C, and at lower temperatures (in the range of 0° to 38°C) with a relatively high modulus of rigidity, of the controlled synthesis conditions of morphology and the shape memory properties, including long homoblocks and short mixed sequences derived from comonomers used, having the formula 7,          -(AAAA)n-(ABAB)k-(BBBB)m-     Formula 7 where n, k and m represent a natural number from 2 to 200, the component of unit A is a group of formula -O-CH(R)-CO-, -O-(CHR)4···6-CO- and / or -O-(CHR)4···6 -O-CO-, in which R is -(CH2)aR1 or -(CHR2-OCH2)b-OH or -(CHR2-OCH2)b-NH2, where a is an integer from 0 to 10, b is an integer from 1 to 1000, R1 is -H or -OH or -NH2, R2 is -CH3 or -CH2CH3, and the component of unit B is a group of formula -O-CH2-CO-, and/or -O-(CH2)4···6-CO-, and/or -O(CH2)4···6-O-CO-. The present invention relates to a process for preparation of bioresorbable polymeric materials with shape memory of the process consists in carrying out the copolymerization, running according to the known mechanism of ROP, the above-mentioned monomers. t-butoxy zirconium (IV), titanium acetylacetonate (IV).

  可生物吸收的全生物相容性热塑性塑料，尤其是无定形热塑性塑料，它们是脂肪族共聚聚酯或脂肪族聚（酯-碳酸酯）或聚（酯-碳酸酯-酰胺），以及聚（酯-碳酸酯-碳酸酯-酰胺）或聚（酰胺-碳酸酯），它们在温度略高于人体温度（38-45°C）的范围内表现出弹性特性，在较低温度（0°至 38°C）的范围内表现出相对较高的刚性模量、在较低温度下（0°至 38°C）具有相对较高的刚性模量、形态和形状记忆特性的受控合成条件，包括所用共聚单体衍生的长均质体和短混合序列，具有式 7、 -(AAAA)n-(ABAB)k-(BBBB)m- 式 7 其中 n、k 和 m 代表 2 至 200 之间的自然数，单元 A 的组分是式-O-CH(R)-CO-、-O-(CHR)4--6-CO- 和/或-O-(CHR)4--6-O-CO-的基团，其中 R 是-(CH2)aR1 或-(CHR2-OCH2)b-OH 或-(CHR2-OCH2)b-NH2、其中 a 是 0 至 10 的整数，b 是 1 至 1000 的整数，R1 是-H 或-OH 或-NH2，R2 是-CH3 或-CH2CH3，单元 B 的组分是式-O-CH2-CO-，和/或-O-(CH2)4--6-CO-，和/或-O(CH2)4--6-O-CO-的基团。本发明涉及一种制备具有形状记忆的生物可吸收高分子材料的工艺，该工艺包括根据已知的 ROP 机理对上述单体进行共聚。
• A process for the preparation of a graft copolymer comprising a polyolefin main chain and one or a multiple polymer side chains and the products obtained therefrom
  申请人：SABIC Global Technologies B.V.

  公开号：EP3034544A1

  公开（公告）日：2016-06-22

  The present invention relates to a cascade process for the preparation of a graft copolymer comprising a polyolefin main chain and one or a multiple polymer side chains. The process comprising step A) of copolymerizing at least one first type of olefin monomer and at least one second type of metal-pacified functionalized olefin monomer using a catalyst system to obtain a polyolefin main chain having one or multiple metal-pacified functionalized short chain branches, the catalyst system comprising: i) a metal catalyst or metal catalyst precursor comprising a metal from Group 3-10 of the IUPAC Periodic Table of elements; and ii) optionally a co-catalyst; and step B) of forming one or multiple polymer side chains on the polyolefin main chain having one or multiple metal-pacified functionalized short chain branches to obtain the graft copolymer.

  本发明涉及一种级联工艺，用于制备包含聚烯烃主链和一个或多个聚合物侧链的接枝共聚物。该工艺包括步骤 A)，使用催化剂体系共聚至少一种第一类烯烃单体和至少一种第二类金属化官能化烯烃单体，以获得具有一个或多个金属化官能化短链分支的聚烯烃主链，催化剂体系包括：i) 金属催化剂或金属催化剂前体，包括 IUPAC 元素周期表第 3-10 族金属；以及 ii) 可选的助催化剂；以及步骤 B) 在具有一个或多个金属acified 功能化短链分支的聚烯烃主链上形成一个或多个聚合物侧链，以获得接枝共聚物。