2-(5-pentyl-1,2,4-oxadiazol-3-yl)pyridine | 425390-26-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(5-pentyl-1,2,4-oxadiazol-3-yl)pyridine
• 英文别名: 5-pentyl-3-pyridin-2-yl-1,2,4-oxadiazole
• CAS: 425390-26-7
• 化学式: C₁₂H₁₅N₃O
• 分子量: 217.271
• InChiKey: PHTXHPMFXNJLKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-吡啶基脒肟 、 己酸酐 以 neat (no solvent) 为溶剂， 反应 0.08h， 以95%的产率得到2-(5-pentyl-1,2,4-oxadiazol-3-yl)pyridine
  参考文献：
  名称：

  Efficient and Convenient Protocol for the Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using HClO₄-SiO₂ as a Heterogeneous Recyclable Catalyst

  摘要：

  Silica-supported perchloric acid (HClO4-SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.

  DOI：

  10.1080/00397911.2014.883633

文献信息

• Efficient and Convenient Protocol for the Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using HClO₄-SiO₂ as a Heterogeneous Recyclable Catalyst
  作者：Ramu Tadikonda、Mangarao Nakka、Mahaboob Basha Gajula、Srinuvasarao Rayavarapu、Padma Rao Gollamudi、Siddaiah Vidavalur

  DOI：10.1080/00397911.2014.883633

  日期：2014.7.3

  Silica-supported perchloric acid (HClO4-SiO2) was found to be a new, highly efficient, inexpensive, and reusable catalyst for a rapid and efficient synthesis of various 1,2,4-oxadiazoles with good to excellent yields under solvent-free conditions. The present methodology has been effectively utilized for the synthesis of oxolamine, an anti-inflammatory drug.