N-(2-hydroxyethyl)-2-oxo-2-phenylacetamide | 90922-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-hydroxyethyl)-2-oxo-2-phenylacetamide
• 英文别名: Phenylglyoxylsaeure-<2-hydroxy-ethylamid>
• CAS: 90922-42-2
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: JMKCLAXRSXPCLQ-UHFFFAOYSA-N

物化性质

• 沸点：
  170 °C(Press: 0.02 Torr)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲酰甲酸 以 二氯甲烷 为溶剂， 反应 1.33h， 生成 N-(2-hydroxyethyl)-2-oxo-2-phenylacetamide
  参考文献：
  名称：

  以 Ynamides 为偶联剂从 α-酮酸和胺一锅法合成 α-Ketoamides

  摘要：

  通过在极其温和的反应条件下使用ynamides作为偶联试剂，开发了一种α-酮酰胺键形成的一锅法。对于 36 个实例，不同结构的 α-酮酰胺的产率高达 98%。该反应具有偶联过程实用、官能团耐受性广、条件极其温和等优点，在合成和药物化学中具有潜在的应用价值。

  DOI：

  10.1021/acs.joc.1c02453

文献信息

• Environmentally friendly transesterification and transacylation reactions under LiBr catalysis
  作者：M. Saeed Abaee、Elahe Akbarzadeh、Roholah Sharifi、Mohammad M. Mojtahedi

  DOI：10.1007/s00706-010-0325-1

  日期：2010.7

  AbstractA room-temperature, convenient transesterification of various esters, induced by catalytic amounts of lithium bromide and diethylamine in a solvent-free environment, is described. Products are obtained in good purity by simple filtration to remove the catalyst and evaporation of the volatile portion. The procedure has also been successfully applied to transacetylation and aminolysis of esters

  摘要描述了在无溶剂环境中由催化量的溴化锂和二乙胺引发的各种酯的室温便捷酯交换反应。通过简单的过滤除去催化剂和蒸发挥发性部分而获得高纯度的产物。该方法也已成功地用于酯的转乙酰和氨解。 图形概要
• Compounds
  申请人：Kaouas Abdelmajid

  公开号：US20120093742A1

  公开（公告）日：2012-04-19

  A method of modulating the flavour of an orally-receivable product, such as a foodstuff, beverage, dentifrice or medicine, comprising the addition thereto of a flavour-modulating proportion of at least one compound of the formula I in which X is selected from CHOH, C═O, CH 2 —CO and CH═C(OH), Y is selected from C1-C7 linear and branched alkyl and CH 2 CH 2 OH, Z is selected from CH 3 and a moiety of the formula II in which the wavy bond represents bond linking Z to X and R 1 and R 2 are selected from the possibilities (i) both hydrogen; (ii) independently OH and OCH 3 ; and (iii) R 1 and R 2 together with their bonds to the phenyl ring form a ring of the formula —O—CH 2 —O—; such that, when Z is CH 3 , X is C═O and Y is CH 2 CH 2 OH.

  一种调节口服产品（如食品、饮料、牙膏或药品）风味的方法，包括向其中添加至少一种化合物的调味比例，该化合物的公式为I，其中X从CHOH、C═O、CH2—CO和CH═C(OH)中选择，Y从C1-C7线性和支链烷基和CH2CH2OH中选择，Z从CH3和公式II中的一个基团中选择，其中波浪线代表将Z与X连接的键，R1和R2从以下可能性中选择：(i) 都是氢；(ii) 独立的OH和OCH3；以及(iii) R1和R2与它们与苯环的键一起形成公式—O—CH2—O—的环；当Z为CH3，X为C═O，Y为CH2CH2OH时。
• Alternative crosslinking mechanisms for polyurethane-based systems
  申请人：COVESTRO LLC

  公开号：US11427673B2

  公开（公告）日：2022-08-30

  The present invention provides compositions comprising the reaction product of an aliphatic diisocyanate, and a reactive intermediate made from one selected from the group consisting of oxazolidinones, benzoic sulfimides (saccharins), 1H-indole-2,3-diones (isatins), succinamides, N-hydroxysuccinamides, 4-hydroxy-3-methoxybenzaldehydes (vanillins), α-ketoamides, piperazines, benzofuranones, 3,4-dihydroxycyclobut-3-ene-1,2-diones (squaric acids), squaric acid esters, α-ketoamides, anilines, and α-ketoamide, phenols. The aliphatic diisocyanate comprises one selected from the group consisting of isocyanurates, biurets, iminooxadiazine diones, urethanes, uretdiones, carbodiimides, and allophanates. The resulting compositions may be useful in producing coatings, adhesives, sealants, castings, composites and films having durability, color stability, high gloss, and chemical resistance properties similar to those made from polyurethane.

  琥珀酰胺、N-羟基琥珀酰胺、4-羟基-3-甲氧基苯甲醛（香兰素）、α-酮酰胺、哌嗪、苯并呋喃酮、3,4-二羟基环丁-3-烯-1,2-二酮（方酸）、方酸酯、α-酮酰胺、苯胺和α-酮酰胺、酚。脂肪族二异氰酸酯包括选自异氰尿酸盐、双脲酸盐、亚胺氧二嗪二酮、氨基甲酸酯、脲二酮、碳化二亚胺和异番酸盐组成的组。所得组合物可用于生产涂料、粘合剂、密封剂、铸件、复合材料和薄膜，其耐久性、颜色稳定性、高光泽度和耐化学性与聚氨酯制成的产品相似。
• Biekert,E.; Sonnenbichler,J., Chemische Berichte, 1961, vol. 94, p. 2785 - 2791
  作者：Biekert,E.、Sonnenbichler,J.

  DOI：——

  日期：——
• COMPOUNDS
  申请人：Givaudan SA

  公开号：EP2445359A1

  公开（公告）日：2012-05-02