Hexanamide, N-isopropyl | 61601-62-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Hexanamide, N-isopropyl
• 英文别名: N-propan-2-ylhexanamide
• CAS: 61601-62-5
• 化学式: C₉H₁₉NO
• mdl: MFCD03378118
• 分子量: 157.256
• InChiKey: YVMILMYSJMSHNO-UHFFFAOYSA-N

物化性质

• 沸点：
  239.6±8.0 °C(Predicted)
• 密度：
  0.857±0.06 g/cm3(Predicted)
• 保留指数：
  1258

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  tert-butyl N-hexanoyl-N-propan-2-ylcarbamate 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以94%的产率得到Hexanamide, N-isopropyl
  参考文献：
  名称：

  温和的铜催化酰胺脱保护策略：使用叔丁基作为保护基

  摘要：

  在合成化学中，用于有机底物脱保护的温和方法至关重要。报道了一种使用催化量的Cu（OTf）2的新的室温方法。这允许使用叔丁基作为酰胺保护基。该方法还扩展到Boc脱保护。

  DOI：

  10.1016/j.tet.2014.07.080

文献信息

• BOTTLEBRUSH COPOLYMERS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20180094099A1

  公开（公告）日：2018-04-05

  Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

  提供延长一个或多个治疗剂释放的材料（例如，颗粒、水凝胶）是药物传递的有用平台。在某种程度上，本发明涉及可用于制备颗粒和水凝胶以延长治疗剂释放的新三嵌段（ABC）瓶刷共聚物。在某些实施例中，本文描述的三嵌段瓶刷共聚物、颗粒和水凝胶对温度敏感，并在生理温度下凝胶（例如，在给予受试者后），提供可用于延长释放药物传递的可注射和/或可植入凝胶。本发明还提供了延长释放药物传递的方法，以及使用创新共聚物、颗粒和水凝胶治疗和/或预防受试者疾病或症状的方法。此外，本发明提供了制备本文描述的三嵌段瓶刷共聚物的方法。
• [EN] 3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS<br/>[FR] UTILISATION DE COMPOSES HETEROARYLES A SUBSTITUTION 3-ALKYLIDENEHYDRAZINO EN TANT QU'ACTIVATEURS DU RECEPTEUR DE LA THROMBOPOIETINE
  申请人：NISSAN CHEMICAL IND LTD

  公开号：WO2004108683A1

  公开（公告）日：2004-12-16

  A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14; aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10; alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14; aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

  化合物的结构式（1）如下：其中A是氮原子或CR4，B是氧原子、硫原子或NR9（但当A是氮原子时，B不是NH），R1是C2-14芳基，L1是键，CR10R11、氧原子、硫原子或NR12，X是OR13、SR13或NR14NR15，R2是氢原子、甲酰基、C1-10烷基或类似物，L2是键或类似物，L3是键，CR17R18、氧原子、硫原子或NR19，L4是键，CR20R21、氧原子、硫原子或NR22，Y是氧原子、硫原子或NR23，R3是C2-14芳基、化合物的互变异构体、前药或药学上可接受的盐或其溶剂化合物。
• HIV REPLICATION INHIBITOR
  申请人：Shionogi & Co., Ltd.

  公开号：US20140249306A1

  公开（公告）日：2014-09-04

  The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein, a broken line means the presence or absence of a bond; R 1 is substituted or unsubstituted alkyl etc., R 2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R 3 is a substituted or unsubstituted aromatic carbocyclic group; R 4 is a hydrogen atom etc.; R 5 is a substituted or unsubstituted aromatic carbocyclic group etc.; Y is a single bond etc.; R 6 is substituted or unsubstituted alkyl; R 7 is —Z—R 71 etc.; Z is —NR 72 —CO— etc.; R 71 is substituted or unsubstituted alkyl etc.; R 72 is a hydrogen atom etc.

  本发明提供了一种具有抗病毒作用的新化合物，特别是具有抑制HIV复制作用的化合物，以及一种药物组合物，特别是一种抗HIV药物。其中，虚线表示键的存在或不存在；R1是取代或未取代的烷基等，R2是取代或未取代的烷氧基等；n为1或2；R3是取代或未取代的芳香环烷基；R4是氢原子等；R5是取代或未取代的芳香环烷基等；Y是单键等；R6是取代或未取代的烷基；R7是—Z—R71等；Z是—NR72—CO—等；R71是取代或未取代的烷基等；R72是氢原子等。
• [EN] ARACHIDONIC ACID ANALOGS AND METHODS FOR ANALGESIC TREATMENT USING SAME<br/>[FR] ANALOGUES DE L'ACIDE ARACHIDONIQUE ET PROCÉDÉS POUR UN TRAITEMENT ANALGÉSIQUE L'UTILISANT
  申请人：CYTOMETIX INC

  公开号：WO2011066414A1

  公开（公告）日：2011-06-03

  The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of r manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. The analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.

  本发明提供了花生四烯酸（AA）类似物以及含有这些类似物作为活性剂的组合物，用于镇痛治疗。提供了制造创新化合物的各种方法，并描述了包括注射剂和口服剂量在内的药物配方。这些类似物还可用作退热组合物以及相关的降热治疗。
• Thoination of N-alkyl-O-acyl hydroxamic acid derivatives via Lawesson's reagent
  作者：Yasair S.S. Al-Faiyz

  DOI：10.1016/j.molstruc.2021.131497

  日期：2022.2

  N-alkyl-O-acyl thiohydroxamic acid derivatives were prepared in good yields by the treatment of their parent hydroxamic acids with Lawesson's reagent. Some of these thiohydroxamic acid derivatives exhibit the ability to undergo rearrangement under basic conditions possibly via [3,3]-sigmatropic in moderate to good yields similar to their parent hydroxamic acids.

  N-烷基-O-酰基硫代异羟肟酸衍生物通过用劳森试剂处理它们的母体异羟肟酸以良好的产率制备。这些硫代异羟肟酸衍生物中的一些表现出在碱性条件下可能通过[3,3]-sigmatropic 以中等至良好产率进行重排的能力，类似于其母体异羟肟酸。