N-(2-hydroxy-1-hydroxymethyl-ethyl)-2-(pyren-1-yl)-acetamide | 496811-48-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: N-(2-hydroxy-1-hydroxymethyl-ethyl)-2-(pyren-1-yl)-acetamide
• 英文别名: N-(1,3-dihydroxypropan-2-yl)-2-pyren-1-ylacetamide
• CAS: 496811-48-4
• 化学式: C₂₁H₁₉NO₃
• 分子量: 333.387
• InChiKey: XYOVKNWGRUBHJY-UHFFFAOYSA-N

物化性质

• 沸点：
  689.7±55.0 °C(Predicted)
• 密度：
  1.357±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxy-1-hydroxymethyl-ethyl)-2-(pyren-1-yl)-acetamide 在 吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 N-[1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]-2-pyren-1-ylacetamide
  参考文献：
  名称：

  New ligand combinations for the efficient stabilization of short nucleic acid hairpins

  摘要：

  Short nucleic acid hairpins (one or two base-pair stems) were strongly stabilized by simple chemical modifications. Non-nucleosidic pyrene or naphtalene diimide derivatives were appended at both 3' and 5' nearby ends of 2'-OMe RNA hairpins, yielding a very large increase in melting temperatures of the modified structures (from +21 to +55degreesC). The excimer formation between the two consecutive pyrene units is in favor of end-stacked pyrenyl rings. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(02)00876-1
• 作为产物：
  描述：

  1-芘乙酸 、 丝氨醇 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.25h， 以50%的产率得到N-(2-hydroxy-1-hydroxymethyl-ethyl)-2-(pyren-1-yl)-acetamide
  参考文献：
  名称：

  New ligand combinations for the efficient stabilization of short nucleic acid hairpins

  摘要：

  Short nucleic acid hairpins (one or two base-pair stems) were strongly stabilized by simple chemical modifications. Non-nucleosidic pyrene or naphtalene diimide derivatives were appended at both 3' and 5' nearby ends of 2'-OMe RNA hairpins, yielding a very large increase in melting temperatures of the modified structures (from +21 to +55degreesC). The excimer formation between the two consecutive pyrene units is in favor of end-stacked pyrenyl rings. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(02)00876-1

文献信息

• New ligand combinations for the efficient stabilization of short nucleic acid hairpins
  作者：Justine Michel、Katell Bathany、Jean-Marie Schmitter、Jean-Pierre Monti、Serge Moreau

  DOI：10.1016/s0040-4020(02)00876-1

  日期：2002.9

  Short nucleic acid hairpins (one or two base-pair stems) were strongly stabilized by simple chemical modifications. Non-nucleosidic pyrene or naphtalene diimide derivatives were appended at both 3' and 5' nearby ends of 2'-OMe RNA hairpins, yielding a very large increase in melting temperatures of the modified structures (from +21 to +55degreesC). The excimer formation between the two consecutive pyrene units is in favor of end-stacked pyrenyl rings. (C) 2002 Published by Elsevier Science Ltd.