5-Cyano-2-methoxy-N-[2-(3-methoxymethoxy-2'-methylthiobiphenyl-4-yl)ethyl]benzenesulfonamide | 409359-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Cyano-2-methoxy-N-[2-(3-methoxymethoxy-2'-methylthiobiphenyl-4-yl)ethyl]benzenesulfonamide
• 英文别名: 5-cyano-2-methoxy-N-[2-[2-(methoxymethoxy)-4-(2-methylsulfanylphenyl)phenyl]ethyl]benzenesulfonamide
• CAS: 409359-32-6
• 化学式: C₂₅H₂₆N₂O₅S₂
• 分子量: 498.624
• InChiKey: HCRJXTFELLVHSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5-Cyano-2-methoxy-N-[2-(3-methoxymethoxy-2'-methylthiobiphenyl-4-yl)ethyl]benzenesulfonamide 在 Oxone 、 碳酸氢钠 作用下， 以 水 、 丙酮 为溶剂， 反应 3.25h， 生成 5-cyano-N-[2-(2'-methanesulfonyl-3-methoxymethoxybiphenyl-4-yl)ethyl]-2-methoxybenzenesulfonamide
  参考文献：
  名称：

  EP1491187

  摘要：

  公开号：
• 作为产物：
  描述：

  4-[2-(5-cyano-2-methoxybenzenesulfonylamino)ethyl]-3-methoxymethoxyphenyl trifluoromethanesulfonate 、 2-甲硫基苯硼酸 在 三苯基膦钯 四丁基溴化铵 、 sodium 作用下， 以 水 、 甲苯 为溶剂， 生成 5-Cyano-2-methoxy-N-[2-(3-methoxymethoxy-2'-methylthiobiphenyl-4-yl)ethyl]benzenesulfonamide
  参考文献：
  名称：

  5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION

  摘要：

  公开号：

  EP1331221B1

文献信息

• 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
  申请人：Okazaki Kosuke

  公开号：US20060116361A1

  公开（公告）日：2006-06-01

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 is a hydrogen atom or an optionally substituted lower alkyl group; R 2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

  本发明涉及一种由通式表示的5-酰胺基-2-羟基苯磺酰胺衍生物：其中，R1是氢原子或可选择取代的较低烷基基团；R2是二（较低烷基）氨基基团、较低烷基基团、环烷基团、可选择取代的芳基基团、可选择取代的杂环烷基基团或可选择取代的芳香族杂环基团；T是氧原子、硫原子、磺酰基等；Q是氢原子或可选择取代的较低烷基基团；Z是氢原子、羟基等，或其药学上可接受的盐，具有强效和选择性的活化血凝因子X抑制活性，可用作预防或治疗与活化血凝因子X相关的疾病的药物，包括该药物的制剂、药物用途和中间体。
• Preventive or therapeutic agent for kidney disease
  申请人：Koizumi Takashi

  公开号：US20050107354A1

  公开（公告）日：2005-05-19

  The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 is a hydrogen atom or an optionally substituted alkyl group; R 2 is a dialkylamino group, an alkyl group, a cycloalkyl group, an optionally substituted aryl group etc.; T is an oxygen atom, a sulfur atom etc.; Q is a hydrogen atom or an optionally substituted alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof which has an inhibitory effect on mesangial cell proliferation and a decreasing effect on protein excretion in urine, and are useful for preventing or treating of various renal diseases such as IgA nephropathy, diabetic nephropathy, nephritic syndrome and the like.

  本发明涉及一种用于预防或治疗肾脏疾病的药剂，其包含作为活性成分的5-酰胺基-2-羟基苯磺酰胺衍生物，其表示为通式： 其中，R1是氢原子或可选取代的烷基基团；R2是二烷基氨基基团、烷基基团、环烷基团、可选取代的芳基基团等；T是氧原子、硫原子等；Q是氢原子或可选取代的烷基基团；Z是氢原子、羟基等，或其药学上可接受的盐，具有对系膜细胞增殖的抑制作用和对尿蛋白排泄的降低作用，适用于预防或治疗各种肾脏疾病，如IgA肾病、糖尿病肾病、肾炎综合症等。
• Novel crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative
  申请人：Mukaiyama Harunobu

  公开号：US20050143457A1

  公开（公告）日：2005-06-30

  The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2′-methanesulfonyl-3-yloxy] acetate hydrochloride, pharmaceutical compositions containing the same and their uses, which exhibits excellent inhibitory activities against activated blood coagulation factor X, and is useful for the treatment or prevention of a tromboembolic disease.

  本发明提供了一种新的结晶形式的n-丁基[4-[2-[2-羟基-5-(N-羟基甲酰基)苯磺酰胺乙基]-2'-甲磺酰基-3-氧基]乙酸盐酸盐，以及包含该物质的制药组合物及其用途，该物质对活化的血凝血因子X具有出色的抑制活性，可用于治疗或预防血栓栓塞性疾病。
• Crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：US07256215B2

  公开（公告）日：2007-08-14

  The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2′-methanesulfonyl-3-yloxy] acetate hydrochloride, pharmaceutical compositions containing the same and their uses, which exhibits excellent inhibitory activities against activated blood coagulation factor X, and is useful for the treatment or prevention of a tromboembolic disease.

  本发明提供了一种新的n-丁基[4-[2-[2-羟基-5-(N-羟基氨基甲酰基)苯磺酰胺]乙基]-2'-甲磺酰基-3-氧基]乙酸盐酸盐的晶型、含有该晶型的制药组合物及其用途，该晶型对活化的血凝血因子X具有优异的抑制活性，可用于治疗或预防血栓栓塞性疾病。
• 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：US07217832B2

  公开（公告）日：2007-05-15

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

  本发明涉及一种由通式表示的5-酰胺基-2-羟基苯磺酰胺衍生物： 其中，R1是氢原子或可选取代的低级烷基基团； R2是二(低级烷基)氨基基团、低级烷基基团、环烷基基团、可选取代的芳基基团、可选取代的杂环烷基基团或可选取代的芳香族杂环基团； T是氧原子、硫原子、磺酰基等； Q是氢原子或可选取代的低级烷基基团； Z是氢原子、羟基等，或其药学上可接受的盐，它具有强效和选择性的活化血凝因子X抑制活性，有用于预防或治疗与活化血凝因子X相关的疾病的药剂，包括该药物组成物、药物用途和其中间体。