4-bromo-2-(2-hydroxy-4-methoxybenzyl)-5-methoxyphenol | 1417423-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-2-(2-hydroxy-4-methoxybenzyl)-5-methoxyphenol
• 英文别名: 4-Bromo-2-[(2-hydroxy-4-methoxyphenyl)methyl]-5-methoxyphenol；4-bromo-2-[(2-hydroxy-4-methoxyphenyl)methyl]-5-methoxyphenol
• CAS: 1417423-46-1
• 化学式: C₁₅H₁₅BrO₄
• 分子量: 339.186
• InChiKey: CLUWLUIREAYXNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲氧基苯酚 、 5-bromo-4-methoxy-2-methoxymethyloxybenzyl acetate 在 p-toluenesulfonic acid immobilized on silica 作用下， 以 乙醇 、 甲苯 为溶剂， 以95%的产率得到4-bromo-2-(2-hydroxy-4-methoxybenzyl)-5-methoxyphenol
  参考文献：
  名称：

  Facile synthesis of diarylmethanes via quinone methides

  摘要：

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.087

文献信息

• Facile synthesis of diarylmethanes via quinone methides
  作者：Kassrin Tangdenpaisal、Wong Phakhodee、Somsak Ruchirawat、Poonsakdi Ploypradith

  DOI：10.1016/j.tet.2012.10.087

  日期：2013.1

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.