3-(1H-吡咯-2-基)-L-丙氨酸

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-(1H-吡咯-2-基)-L-丙氨酸
• 中文别名: 1,2-苯二醇,3-乙基-
• 英文名称: (2S)-2-azaniumyl-3-(1H-pyrrol-2-yl)propanoate
• 化学式: C7H10N2O2
• 分子量: 154.17
• InChiKey: REBWUCRWJNKVLL-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Monomethylvaline Compounds Having Phenylalanine Side-Chain Replacements at the C-Terminus
  申请人：Doronina Svetlana O.

  公开号：US20090018086A1

  公开（公告）日：2009-01-15

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供了MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类类似物，其中包括C-末端苯丙氨酸残基侧链替换或修饰，这些类似物可以单独提供或通过各种连接剂连接到配体上。相关的结合物可以针对特定细胞类型，提供治疗效果。
• MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS
  申请人：Seattle Genetics, Inc.

  公开号：US20130123465A1

  公开（公告）日：2013-05-16

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供了MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类类似物，其具有C-末端苯丙氨酸残基侧链替换或修饰，可单独提供或通过各种连接剂连接到配体上。相关的结合物可以定向特定的细胞类型，以提供治疗效益。
• Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
  申请人：UNIVERSITY OF MIAMI

  公开号：EP0048159A2

  公开（公告）日：1982-03-24

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula Wherein X = X, O or NR9, R4 and R5 form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 X = X、O 或 NR9，R4 和 R5 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自已公开的各种基团。
• Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
  申请人：Ryan, James Walter

  公开号：EP0073143A2

  公开（公告）日：1983-03-02

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula wherein R, and/or R3 form complex amides and imides thereof, X = S, O or NR3, R4 and Rs form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 R 和/或 R3 形成其复合酰胺和亚胺，X = S、O 或 NR3，R4 和 Rs 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自各种已公开的基团。
• Novel platelet-aggregation inhibitors
  申请人：MONSANTO COMPANY

  公开号：EP0454651A2

  公开（公告）日：1991-10-30

  Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure wherein    x = 4 to 8,    y = 0 to 4,    W = CH₂-CH₂ or CH=CH,    Z = H, COOH, CONH₂, CH₂OH, CO₂R, CH₂OR or C₁₋₆ alkyl,    R = C₁₋₆ alkyl,    Ar = a nitrogen-containing heterocyclic group other than pyridyl, and    Asp = aspartic acid residue.

  本研究提供了新型肽模拟化合物，它们作为血小板聚集抑制剂具有有用的活性。这些化合物的化学结构如下 其中 x = 4 至 8 y = 0 至 4、 W = CH₂-CH₂ 或 CH=CH、 Z = H、COOH、CONH₂、CH₂OH、CO₂R、CH₂OR 或 C₁₋₆ 烷基、 R = C₁₋₆烷基、 Ar = 除吡啶基以外的含氮杂环基团，以及 Asp = 天冬氨酸残基。