6-Cyclohexyl-3-methoxy-phenol | 30312-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-Cyclohexyl-3-methoxy-phenol
• 英文别名: 2-Cyclohexyl-5-methoxyphenol
• CAS: 30312-01-7
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: XKSMVIXRDXSUHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲氧基苯酚 、 环己醇 在 环戊烯 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以95%的产率得到6-Cyclohexyl-3-methoxy-phenol
  参考文献：
  名称：

  酚与醇的脱水 C–H 烷基化和烯基化：取代酚和苯并呋喃的便利合成

  摘要：

  明确定义的阳离子 Ru-H 络合物催化苯酚与醇的脱水 CH 烷基化反应，形成邻位取代的苯酚产物。苯并呋喃衍生物是由苯酚与 1,2-二醇的脱水 CH 烯基化和环化反应有效合成的。催化 CH 偶联方法使用廉价的酚类和醇类，表现出广泛的底物范围，耐受羰基和胺官能团，并释放水作为唯一的副产物。

  DOI：

  10.1021/ja302710v

文献信息

• Novel resorcinol derivatives for skin
  申请人：Harichian Bijan

  公开号：US20060210498A1

  公开（公告）日：2006-09-21

  New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening: Wherein X 1 and/or X 2 represents hydrogen (H), linear or branched, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, or acyl groups. Preferably, X 1 and/or X 2 represents hydrogen (H); linear or branched, saturated or unsaturated C 1 -C 12 alkyl or acyl groups; R 1 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group. Preferably, R 1 represents hydrogen (H) or a C 1 alkyl group (i.e, methyl group). More preferably, R 1 represents hydrogen; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

  一种通式I和/或B的新的4-取代邻苯二酚衍生物，以及其合成方法、化妆品组合物和使用方法，特别用于皮肤美白：其中X1和/或X2表示氢（H）、线性或支链、饱和或不饱和的C1-C12烷基、烯基或酰基。优选地，X1和/或X2表示氢（H）；线性或支链、饱和或不饱和的C1-C12烷基或酰基；R1表示氢（H）、线性或支链、环状或非环状、饱和或不饱和的C1-C12烷基、烯基、环烷基或环烯基。更优选地，R1表示氢（H）或C1烷基（即甲基）。更具体地，R1表示氢；n表示0或1。当n=0时，环是一个环戊基，可以有一个来自O、N或S的杂原子和/或一个双键。当n=1时，环是一个环己基，可以有一个来自O、N或S的杂原子和/或一个双键；m表示1到6之间的整数。
• Novel Resorcinol Derivatives for Skin
  申请人：Harichian Bijan

  公开号：US20080131382A1

  公开（公告）日：2008-06-05

  New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening: Wherein X 1 and/or X 2 represents hydrogen (H), linear or branched, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, or acyl groups. Preferably, X 1 and/or X 2 represents hydrogen (H); linear or branched, saturated or unsaturated C 1 -C 12 alkyl or acyl groups; R 1 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group. Preferably, R 1 represents hydrogen (H) or a C 1 alkyl group (i.e, methyl group). More preferably, R 1 represents hydrogen; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.

  新的4-取代邻苯二酚衍生物的一般式I和/或B以及其合成方法，化妆品组合物和使用它们的方法，特别是用于皮肤美白的方法： 其中X1和/或X2代表氢（H），线性或支链的，饱和或不饱和的C1-C12烷基，烯基或酰基。优选地，X1和/或X2代表氢（H）；线性或支链的，饱和或不饱和的C1-C12烷基或酰基；R1代表氢（H），线性或支链的，环状或非环状的，饱和或不饱和的C1-C12烷基，烯基，环烷基或环烯基。更优选地，R1代表氢（H）或C1烷基（即甲基基团）。更更优选地，R1代表氢；n代表0或1。当n=0时，环是一个环戊基，带或不带一个来自O、N或S的杂原子和/或一个双键。当n=1时，环是一个环己基，带或不带一个来自O、N或S的杂原子和/或一个双键；m代表1到6之间的整数。
• NOVEL RESORCINOL DERIVATIVES
  申请人：UNILEVER PLC

  公开号：EP1858835A1

  公开（公告）日：2007-11-28
• NOVEL RESORCINOL DERIVATIVES FOR SKIN
  申请人：UNILEVER PLC

  公开号：EP1861353A1

  公开（公告）日：2007-12-05
• Novel resorcinol derivatives
  申请人：Harichian Bijan

  公开号：US20060210497A1

  公开（公告）日：2006-09-21

  New 4-substituted resorcinol derivatives of general formula I and/or B and process for synthesizing same, cosmetic compositions and methods of using same, particularly for skin lightening and/or reducing the appearance of oily or greasy skin: Wherein X 1 and/or X 2 represents hydrogen (H), linear or branched, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, or acyl groups. Preferably, X 1 and/or X 2 represents hydrogen (H); linear or branched, saturated or unsaturated C 1 -C 12 alkyl or acyl groups; R 1 and/or R 2 represents hydrogen (H), linear or branched, cyclic or acyclic, saturated or unsaturated C 1 -C 12 alkyl, alkenyl, cycloalkyl, or cycloalkenyl group; n represents 0, 1. When n=0, the ring is a cyclopentyl with or without one heteroatom from O, N or S and/or with or without one double bond. When n=1, the ring is a cyclohexyl with or without one heteroatom from O, N or S and/or with or without one double bond; and m represents an integer between 1 and 6.