1-(2,6-difluorophenyl)-5-methyl-1H,3H-thiazolo[3,4-a]benzimidazole | 246148-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2,6-difluorophenyl)-5-methyl-1H,3H-thiazolo[3,4-a]benzimidazole
• 英文别名: 1-(2,6-Difluorophenyl)-5-methyl-1,3-dihydrothiazolo[3,4-a]benzimidazole；1-(2,6-difluorophenyl)-5-methyl-1,3-dihydro-[1,3]thiazolo[3,4-a]benzimidazole
• CAS: 246148-51-6
• 化学式: C₁₆H₁₂F₂N₂S
• 分子量: 302.347
• InChiKey: LHZFKOCIRPQAGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二氟苯甲醛 、 巯基乙酸 、 2,3-二氨基甲苯 反应 1.33h， 生成 1-(2,6-difluorophenyl)-8-methyl-1H,3H-thiazolo[3,4-a]benzimidazole 、 1-(2,6-difluorophenyl)-5-methyl-1H,3H-thiazolo[3,4-a]benzimidazole
  参考文献：
  名称：

  An ionic liquid mediated one-pot synthesis of substituted thiazolidinones and benzimidazoles

  摘要：

  An expeditious one-pot synthesis of 2,3-diaryl/2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones and 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles have been accomplished by condensing hetero/aromatic amine, 2-mercaptoacetic acid, aromatic aldehyde and 1,2-phenylenediamine, 2-mercaptoacetic acid and aromatic aldehyde, respectively, in ionic liquids, viz, 1-butyl-3-methyl-imidazolium tetra fluoroborate and 1-methoxyethyl-3-methylimidazolium trifluoroacetate. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.091

文献信息

• An ionic liquid mediated one-pot synthesis of substituted thiazolidinones and benzimidazoles
  作者：Ashok K. Yadav、Manoj Kumar、Tripti Yadav、Renuka Jain

  DOI：10.1016/j.tetlet.2009.06.091

  日期：2009.9

  An expeditious one-pot synthesis of 2,3-diaryl/2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones and 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles have been accomplished by condensing hetero/aromatic amine, 2-mercaptoacetic acid, aromatic aldehyde and 1,2-phenylenediamine, 2-mercaptoacetic acid and aromatic aldehyde, respectively, in ionic liquids, viz, 1-butyl-3-methyl-imidazolium tetra fluoroborate and 1-methoxyethyl-3-methylimidazolium trifluoroacetate. (C) 2009 Elsevier Ltd. All rights reserved.