Ethyl 3-benzyl-2-oxo-1-oxaspiro[4.5]decane-3-carboxylate | 1374015-54-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 3-benzyl-2-oxo-1-oxaspiro[4.5]decane-3-carboxylate
• 英文别名: ethyl 3-benzyl-2-oxo-1-oxaspiro[4.5]decane-3-carboxylate
• CAS: 1374015-54-9
• 化学式: C₁₉H₂₄O₄
• 分子量: 316.397
• InChiKey: AZHLEVMFTNBTDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苄基丙二酸二乙酯 、 亚甲基环己烷 在 ammonium cerium (IV) nitrate 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以27%的产率得到diethyl 2-benzyl-2-(cyclohexenylmethyl)malonate
  参考文献：
  名称：

  Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate

  摘要：

  An easily reproducible protocol allowing inter- or intramolecular spirocyclization on beta-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzophenanthridin-6(5H)-ones and spirolactones were synthesized. These scaffolds could be used for the design of many compounds exhibiting biological activities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.004

文献信息

• Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate
  作者：Ahlem Bouhlel、Christophe Curti、Michèle P. Bertrand、Patrice Vanelle

  DOI：10.1016/j.tet.2012.03.004

  日期：2012.5

  An easily reproducible protocol allowing inter- or intramolecular spirocyclization on beta-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzophenanthridin-6(5H)-ones and spirolactones were synthesized. These scaffolds could be used for the design of many compounds exhibiting biological activities. (C) 2012 Elsevier Ltd. All rights reserved.