UBP 1130 | 339526-75-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: UBP 1130
• 英文别名: I+/--Amino-I+/-,2-dimethyl-4-phosphonobenzeneacetic acid；2-amino-2-(2-methyl-4-phosphonophenyl)propanoic acid
• CAS: 339526-75-9
• 化学式: C₁₀H₁₄NO₅P
• 分子量: 259.199
• InChiKey: DARFORMBFDHIJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  [3-Methyl-4-(4-methyl-2,5-dioxo-imidazolidin-4-yl)-phenyl]-phosphonic acid diethyl ester 在 盐酸 作用下， 生成 UBP 1130
  参考文献：
  名称：

  Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

  摘要：

  The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00052-x

文献信息

• Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors
  作者：Stuart J Conway、Jacqueline C Miller、Patrick A Howson、Barry P Clark、David E Jane

  DOI：10.1016/s0960-894x(01)00052-x

  日期：2001.3

  The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.