3-methyl-4H-benzo[1,4]thiazine 1,1-dioxide | 19111-34-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3-methyl-4H-benzo[1,4]thiazine 1,1-dioxide
• 英文别名: 3-Methyl-4H-1,4-benzothiazin-1,1-dioxid；3-methyl-4H-1lambda6,4-benzothiazine 1,1-dioxide；3-methyl-4H-1λ6,4-benzothiazine 1,1-dioxide
• CAS: 19111-34-3
• 化学式: C₉H₉NO₂S
• 分子量: 195.242
• InChiKey: WBDJXDWPQZEKKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (o-Nitrophenyl-sulfonyl)-aceton 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 生成 3-methyl-4H-benzo[1,4]thiazine 1,1-dioxide
  参考文献：
  名称：

  Pagani,G., Gazzetta Chimica Italiana, 1967, vol. 97, p. 1804 - 1816

  摘要：

  DOI：

文献信息

• One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water–Gas Shift Reaction Utilizing DMF/H₂O
  作者：Yogesh Sharma、Ganesh P. Pawar、Vinod D. Chaudhari

  DOI：10.1021/acs.joc.2c02171

  日期：2023.1.6

  Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water–gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and α-bromo ketones is presented. This strategy is cost-effective and environmentally

  苯并噻嗪 1,1-二氧化物 (BTDO) 是一种特殊的化学基序，其无金属多米诺骨牌通道的需求量很大。目前的 BTDO 生产方法需要昂贵的金属催化剂或苛刻的反应条件。提出了一种通过使用 2-硝基苯亚磺酸钠和 α-溴酮的水煤气变换反应 (WGSR) 生成 BTDO 的简单多米诺骨牌方法。该策略具有成本效益且对环境有益。优化的反应条件对两个偶联伙伴上的各种电学和空间变化的取代基表现出显着的化学耐受性。
• 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS
  申请人：Chen Kevin X.

  公开号：US20100098661A1

  公开（公告）日：2010-04-22

  The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.
• 4, 5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS
  申请人：Anilkumar Gopinadhan N.

  公开号：US20100196319A1

  公开（公告）日：2010-08-05

  The present invention relates to 4,5-ring annulated indole derivatives of formula (I), compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient, wherein ring Z of formula (I), is cyclohexyl, cyclohexenyl, 6-membered heterocycloalkyl, 6-membered heterocycloalkenyl, 6-membered aryl or 6-membered heteroaryl, wherein R 1 , R 2 , R 3 , R 6 , R 7 and R 10 are as described herein.
• US8546420B2
  申请人：——

  公开号：US8546420B2

  公开（公告）日：2013-10-01
• US8557848B2
  申请人：——

  公开号：US8557848B2

  公开（公告）日：2013-10-15