Oxalsaeure-mono-(N'-phenyl-hydrazid) | 51551-64-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Oxalsaeure-mono-(N'-phenyl-hydrazid)
• 英文别名: oxalic acid mono-(N'-phenyl-hydrazide)；2-Oxo-2-(2-phenylhydrazinyl)acetic acid
• CAS: 51551-64-5
• 化学式: C₈H₈N₂O₃
• 分子量: 180.163
• InChiKey: PEVJUUIDURIFOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Oxalsaeure-mono-(N'-phenyl-hydrazid) 在 戴斯-马丁氧化剂 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 2.25h， 生成 3-{3-methyl-2-[(N'-phenyl-hydrazinooxalyl)-amino]-butyrylamino}-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

  摘要：

  Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.106
• 作为产物：
  描述：

  Oxo(2-phenylhydrazino)essigsaeure-methylester 在 lithium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 Oxalsaeure-mono-(N'-phenyl-hydrazid)
  参考文献：
  名称：

  Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

  摘要：

  Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.106

文献信息

• Michael, Journal fur praktische Chemie (Leipzig 1954), 1887, vol. <2> 35, p. 456
  作者：Michael

  DOI：——

  日期：——
• Thiele; Schleussner, Justus Liebigs Annalen der Chemie, 1897, vol. 295, p. 160
  作者：Thiele、Schleussner

  DOI：——

  日期：——
• PETYUNIN G. P., FARMATSEVTICHNIJ ZH., 1980, HO 3, 40-2
  作者：PETYUNIN G. P.

  DOI：——

  日期：——
• COMPOUNDS FOR TREATING INFECTIONS
  申请人：HORITZONTS TECNOLOGICS HUNGARY KORLÁTOLT FELELOSSÉGU TÁRSASÁG

  公开号：US20210155578A1

  公开（公告）日：2021-05-27

  The invention relates to hydrazide compounds and their use in medicine, particularly in treating and/or preventing infections caused by a fungus.
• US3951941A
  申请人：——

  公开号：US3951941A

  公开（公告）日：1976-04-20