4-Chloro-dithiobenzoic acid p-tolyl ester | 165543-77-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-Chloro-dithiobenzoic acid p-tolyl ester
• 英文别名: (4-Methylphenyl) 4-chlorobenzenecarbodithioate
• CAS: 165543-77-1
• 化学式: C₁₄H₁₁ClS₂
• 分子量: 278.826
• InChiKey: BFTXRTJCBGLYJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲氧苯胺 、 4-Chloro-dithiobenzoic acid p-tolyl ester 以 乙腈 为溶剂， 生成 4-chloro-N-(4-methoxyphenyl)benzothioamide
  参考文献：
  名称：

  Oh, Hyuck Keun; Shin, Chul Ho; Lee, Ikchoon, Journal of the Chemical Society. Perkin transactions II, 1995, # 6, p. 1169 - 1174

  摘要：

  DOI：
• 作为产物：
  描述：

  p-Chlorthiobenzoesaeure 在 caesium carbonate 作用下， 以 间二甲苯 、 乙腈 为溶剂， 反应 0.08h， 生成 4-Chloro-dithiobenzoic acid p-tolyl ester
  参考文献：
  名称：

  Ynamide-Mediated Thionoester and Dithioester Syntheses

  摘要：

  A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish alpha-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.

  DOI：

  10.1021/acs.orglett.0c02402

文献信息

• Ynamide-Mediated Thionoester and Dithioester Syntheses
  作者：Chaochao Yao、Jinhua Yang、Xiaobiao Lu、Shuyu Zhang、Junfeng Zhao

  DOI：10.1021/acs.orglett.0c02402

  日期：2020.8.21

  A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish alpha-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.
• Oh, Hyuck Keun; Shin, Chul Ho; Lee, Ikchoon, Journal of the Chemical Society. Perkin transactions II, 1995, # 6, p. 1169 - 1174
  作者：Oh, Hyuck Keun、Shin, Chul Ho、Lee, Ikchoon

  DOI：——

  日期：——