Synthesis of Peptides Employing Protected-Amino Acid Halides Mediated by Commercial Anion Exchange Resin
作者:K. M. Bhaskara Redddy、Y. Bharathi Kumari、Kuppanna Ananda
DOI:10.1007/s10989-012-9337-5
日期:2013.9
AbstractCoupling of protected-amino acid halides (chloride, fluoride) mediated by commercial anion exchange resin for the solution phase synthesis of peptides is described. The reaction was carried out in an organic medium, circumventing the use of an organic base or an inorganic base. The coupling is fast, clean and racemization free. The anion exchange resin functions as a solid-phase basic scavenger
摘要描述了由商业阴离子交换树脂介导的用于肽的溶液相合成的受保护氨基酸卤化物(氯化物,氟化物)的偶联。该反应在有机介质中进行,从而避免了使用有机碱或无机碱。联轴器快速,清洁且无外消旋。阴离子交换树脂起着固相碱性清除剂的作用,吸收产生的HCl,并使胺发生反应。该方法被扩展用于空间位阻的α,α,-二烷基氨基酸的偶联。 图形概要