(R)-tert-butyl (3-butoxy-1-methyl-2-oxoindolin-3-yl)carbamate | 1448538-64-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-tert-butyl (3-butoxy-1-methyl-2-oxoindolin-3-yl)carbamate
• 英文别名: tert-butyl N-[(3R)-3-butoxy-1-methyl-2-oxoindol-3-yl]carbamate
• CAS: 1448538-64-4
• 化学式: C₁₈H₂₆N₂O₄
• 分子量: 334.415
• InChiKey: ZHMVOQFMSANZOY-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl 1-methyl-2-oxoindolin-3-ylidenecarbamate 、 正丁醇 在 C₃₄H₃₀F₆N₄S 作用下， 以 乙醚 为溶剂， 反应 17.0h， 以86%的产率得到
  参考文献：
  名称：

  The 2′-phenyl cinchonidine thiourea-catalyzed asymmetric addition of alcohols to isatin-derived N-Boc ketimines

  摘要：

  Optically active isatin-derived N,0-aminals were obtained through the catalytic asymmetric addition of various alcohols to isatin-derived N-Boc ketimines. Using 2'-phenyl cinchonidine thiourea as the catalyst, adducts were obtained in 96% yield and with up to 92% ee. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2015.08.011

文献信息

• Catalytic enantioselective addition of alcohols to isatin-derived N-Boc ketimines
  作者：Tian-Ze Li、Xi-Bo Wang、Feng Sha、Xin-Yan Wu

  DOI：10.1016/j.tet.2013.06.076

  日期：2013.9

  The enantioselective addition of alcohols to isatin-derived N-Boc ketimines was investigated for the first time. Isatin-derived N,O-aminals were obtained in excellent yields with moderate-to-good enantiose-lectivities (up to 78% ee) in the presence of a quinine-based bifunctional catalyst. (C) 2013 Elsevier Ltd. All rights reserved.
• The 2′-phenyl cinchonidine thiourea-catalyzed asymmetric addition of alcohols to isatin-derived N-Boc ketimines
  作者：Jing Liu、Fang-Meng Zhu、Yun-Bo Chu、Li-Hong Huang、Yi-Feng Zhou

  DOI：10.1016/j.tetasy.2015.08.011

  日期：2015.11

  Optically active isatin-derived N,0-aminals were obtained through the catalytic asymmetric addition of various alcohols to isatin-derived N-Boc ketimines. Using 2'-phenyl cinchonidine thiourea as the catalyst, adducts were obtained in 96% yield and with up to 92% ee. (C) 2015 Elsevier Ltd. All rights reserved.