(2-bromo-2-phenylethoxy)(tert-butyl)dimethylsilane | 245759-95-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-bromo-2-phenylethoxy)(tert-butyl)dimethylsilane
• 英文别名: (1-Bromo-2-t-butyldimethylsilyloxyethyl)benzene；(2-bromo-2-phenylethoxy)-tert-butyl-dimethylsilane
• CAS: 245759-95-9
• 化学式: C₁₄H₂₃BrOSi
• 分子量: 315.326
• InChiKey: JRFGADIANOQVFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  305.1±35.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.14
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2-bromo-2-phenylethoxy)(tert-butyl)dimethylsilane 在 乙醇 、 四丁基氟化铵 、 sodium 作用下， 反应 12.0h， 生成 N-Boc-S-(1-phenyl-2-hydroxyethyl)-L-cysteine
  参考文献：
  名称：

  A facile one-pot synthesis of the very useful building blocks N-Boc-S-alkylatedcysteines

  摘要：

  A convenient one-pot method for the synthesis of N-Boc protected S-alkylcysteines, useful intermediates for the solution-phase synthesis of glutathione-conjugates and modified peptides is presented, together with the reactivity of epoxides, halohydrins and alpha-halo carbonyl derivatives towards the sulfur nucleophile of the substrate. The reactions with alpha-halo esters lead to thiomorpholinocarboxylic acids which are interesting potential inhibitors of transport systems. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00528-1
• 作为产物：
  描述：

  苯基乙二醇 在 咪唑 、 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (2-bromo-2-phenylethoxy)(tert-butyl)dimethylsilane
  参考文献：
  名称：

  [EN] SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR
  [FR] INHIBITEURS DE TSHR SUBSTITUÉS DE 3,4-DIHYDROQUINOLINONE

  摘要：

  Disclosed are compounds that are thyroid stimulating hormone receptor antagonists, and methods useful for preventing or treating a thyroid disease.

  公开号：

  WO2024026076A2

文献信息

• [EN] COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF<br/>[FR] COMPOSÉ PRÉSENTANT UNE ACTIVITÉ INHIBITRICE DE KDM5 ET UTILISATION PHARMACEUTIQUE ASSOCIÉE
  申请人：ONO PHARMACEUTICAL CO

  公开号：WO2021010492A1

  公开（公告）日：2021-01-21

  The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (Z): wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, or Alzheimer's disease and the like.

  本发明提供了KDM5抑制剂。本文所披露的化合物由一般式（Z）表示：其中所有符号的含义与规范中描述的定义相同；或其盐可用作癌症、亨廷顿病或阿尔茨海默病等的预防和/或治疗剂。
• Novel Methodology for the Synthesis of <i>N</i>-Alkoxyamines
  作者：Rebecca Braslau、Anna Tsimelzon、Jennifer Gewandter

  DOI：10.1021/ol049271v

  日期：2004.6.1

  [reaction: see text] We report a new methodology for the synthesis of the N-alkoxyamines, which can be used as initiators in "living" free radical polymerization. Silyl radical abstraction from alkyl halides allows the synthesis of N-alkoxyamines inaccessible by other methods.

  [反应：见正文]我们报告了一种合成N-烷氧基胺的新方法，该方法可用作“活性”自由基聚合反应的引发剂。从卤代烷中提取甲硅烷基可以使其他方法无法合成N-烷氧基胺。
• A facile one-pot synthesis of the very useful building blocks N-Boc-S-alkylatedcysteines
  作者：Sante Cundari、Renato Dalpozzo、Antonio De Nino、Antonio Procopio、Giovanni Sindona、Kostantinos Athanassopulos

  DOI：10.1016/s0040-4020(99)00528-1

  日期：1999.8

  A convenient one-pot method for the synthesis of N-Boc protected S-alkylcysteines, useful intermediates for the solution-phase synthesis of glutathione-conjugates and modified peptides is presented, together with the reactivity of epoxides, halohydrins and alpha-halo carbonyl derivatives towards the sulfur nucleophile of the substrate. The reactions with alpha-halo esters lead to thiomorpholinocarboxylic acids which are interesting potential inhibitors of transport systems. (C) 1999 Elsevier Science Ltd. All rights reserved.
• [EN] SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR<br/>[FR] INHIBITEURS DE TSHR SUBSTITUÉS DE 3,4-DIHYDROQUINOLINONE
  申请人：[en]SEPTERNA, INC.

  公开号：WO2024026076A2

  公开（公告）日：2024-02-01

  Disclosed are compounds that are thyroid stimulating hormone receptor antagonists, and methods useful for preventing or treating a thyroid disease.