ethyl 6-methyl-2-oxo-4-(1,3-thiazol-5-yl)-3,4-dihydro-1H-pyrimidine-5-carboxylate | 1372469-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: ethyl 6-methyl-2-oxo-4-(1,3-thiazol-5-yl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
• CAS: 1372469-31-2
• 化学式: C₁₁H₁₃N₃O₃S
• 分子量: 267.309
• InChiKey: VKOKQIKRCHSARE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-噻唑甲醛 、 乙酰乙酸乙酯 、 尿素 在 2,2,2-三氟乙醇 作用下， 以86%的产率得到ethyl 6-methyl-2-oxo-4-(1,3-thiazol-5-yl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
  参考文献：
  名称：

  Trifluoroethanol as a Metal-Free, Homogeneous, and Recyclable Medium for the Efficient One-Pot Synthesis of Dihydropyrimidones

  摘要：

  Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of beta-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.

  DOI：

  10.1080/00397911.2010.525335

文献信息

• Trifluoroethanol as a Metal-Free, Homogeneous, and Recyclable Medium for the Efficient One-Pot Synthesis of Dihydropyrimidones
  作者：S. V. Rashmi、N. C. Sandhya、B. Raghava、M. N. Kumara、K. Mantelingu、K. S. Rangappa

  DOI：10.1080/00397911.2010.525335

  日期：2012.2.1

  Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of beta-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.