7-bromo-1,1,2,2-tetrafluoroindane | 922141-58-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 7-bromo-1,1,2,2-tetrafluoroindane
• 英文别名: 7-Bromo-1,1,2,2-tetrafluoro-2,3-dihydro-1H-indene；4-bromo-2,2,3,3-tetrafluoro-1H-indene
• CAS: 922141-58-0
• 化学式: C₉H₅BrF₄
• 分子量: 269.036
• InChiKey: SQMLWJZMLJPHNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  sodium chlorodifluoroacetate 、 3-溴-beta,beta-二氟苯乙烯 以 二乙二醇二甲醚 为溶剂， 反应 13.0h， 以43%的产率得到5-bromo-1,1,2,2-tetrafluoroindane
  参考文献：
  名称：

  One-pot process to prepare 1,1,2,2-tetrafluoroindane from substituted 2,2-difluorostyrene and sodium chlorodifluoroacetate

  摘要：

  Reaction of 2,2-difluorostyrenes and sodium chlorodifluoroacetate in diglyme solution at 180 degrees C gave 1-aryl-2,2,3,3-tetrafluorocyclopropane as a primary product. After prolong reaction under the same condition, the 1, 1,2,2-tetrafluoroindanes can be isolated as the only product in good yields. All the tetrafluorocyclopropanes and tetrafluoroindanes were well characterized by spectroscopic analyses. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.041

文献信息

• One-pot process to prepare 1,1,2,2-tetrafluoroindane from substituted 2,2-difluorostyrene and sodium chlorodifluoroacetate
  作者：Chuan-Chen Lee、Shaw-Tao Lin、Shun-Ying Ke

  DOI：10.1016/j.tet.2006.10.041

  日期：2007.1

  Reaction of 2,2-difluorostyrenes and sodium chlorodifluoroacetate in diglyme solution at 180 degrees C gave 1-aryl-2,2,3,3-tetrafluorocyclopropane as a primary product. After prolong reaction under the same condition, the 1, 1,2,2-tetrafluoroindanes can be isolated as the only product in good yields. All the tetrafluorocyclopropanes and tetrafluoroindanes were well characterized by spectroscopic analyses. (c) 2006 Elsevier Ltd. All rights reserved.

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