RF2 | 66127-60-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: RF2
• 英文别名: Bz-Arg-Phe-NH2；N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]benzamide
• CAS: 66127-60-4
• 化学式: C₂₂H₂₈N₆O₃
• 分子量: 424.503
• InChiKey: AYCCDRRQDKILDD-ROUUACIJSA-N

物化性质

• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-苯丙氨酰胺 、 N-alpha-苯甲酰基-L-精氨酸乙酯盐酸盐 在 水 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 苯 为溶剂， 以98%的产率得到RF2
  参考文献：
  名称：

  Peptide synthesis catalyzed by modified .alpha.-chymotrypsin in low-water organic media

  摘要：

  Enzyme-catalyzed synthesis of peptide bonds in organic solvents has been investigated by using alpha-chymotrypsin either modified with poly(ethylene glycol) or immobilized on different supports, in order to find out the importance of water content in the reaction. High yields of peptide synthesis were obtained whatever the type of enzyme derivative used. By varying the type of support, a modification in the enzyme environment was observed and resulted in a significant increase in the reaction yield when nucleophiles with poor affinity for the enzyme were used. Since organic solvents also affected substrate specificity with respect to the donor ester, a general methodology was proposed for the enzymatic synthesis of peptides in low-water organic media.

  DOI：

  10.1021/jo00009a041

文献信息

• Peptide synthesis catalyzed by modified .alpha.-chymotrypsin in low-water organic media
  作者：H. Gaertner、T. Watanabe、J. V. Sinisterra、A. Puigserver

  DOI：10.1021/jo00009a041

  日期：1991.4

  Enzyme-catalyzed synthesis of peptide bonds in organic solvents has been investigated by using alpha-chymotrypsin either modified with poly(ethylene glycol) or immobilized on different supports, in order to find out the importance of water content in the reaction. High yields of peptide synthesis were obtained whatever the type of enzyme derivative used. By varying the type of support, a modification in the enzyme environment was observed and resulted in a significant increase in the reaction yield when nucleophiles with poor affinity for the enzyme were used. Since organic solvents also affected substrate specificity with respect to the donor ester, a general methodology was proposed for the enzymatic synthesis of peptides in low-water organic media.