methyl 2-chlorocarbonyloxypropionate | 97650-44-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-chlorocarbonyloxypropionate
• 英文别名: methyl 2-[(chlorocarbonyl)oxy]propanoate；Methyl 2-((chlorocarbonyl)oxy)propanoate；methyl 2-carbonochloridoyloxypropanoate
• CAS: 97650-44-7
• 化学式: C₅H₇ClO₄
• 分子量: 166.561
• InChiKey: MKPINVGFDFGYRU-UHFFFAOYSA-N

物化性质

• 沸点：
  171.5±23.0 °C(Predicted)
• 密度：
  1.283±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-chlorocarbonyloxypropionate 在 sodium peroxide 作用下， 以 水 为溶剂， 反应 1.0h， 以63%的产率得到dimethyl 2,2'-((peroxybis(carbonyl))bis(oxy))dipropionate
  参考文献：
  名称：

  Kirillov, A. I.; Ivanova, L. F.; Shilov, G. I., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 2, p. 301 - 305

  摘要：

  DOI：
• 作为产物：
  描述：

  L-乳酸甲酯 、 光气 生成 methyl 2-chlorocarbonyloxypropionate
  参考文献：
  名称：

  CROSBY, J.

  摘要：

  DOI：

文献信息

• Process for Preparing Fluorinated Molecules
  申请人：Geller Thomas

  公开号：US20070287855A1

  公开（公告）日：2007-12-13

  The present invention relates to a process for preparing α-fluorinated esters from α-hydroxy esters by reaction with a dihalocarbonyl compound (or an equivalent) to give haloformates and further to give fluoroformates, which are then decomposed thermally in the presence of suitable catalysts. The invention further relates to the individual steps of the process and in some cases to novel fluoroformates.

  本发明涉及一种从α-羟基酯通过与二卤代羰基化合物（或等效物）反应制备α-氟酯的方法，生成卤代甲酸酯，进一步生成氟甲酸酯，然后在适当催化剂的存在下进行热分解。本发明还涉及该过程的各个步骤，有时还涉及新型氟甲酸酯。
• 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof
  申请人：Uchida Masahiko

  公开号：US20050014787A1

  公开（公告）日：2005-01-20

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

  本发明涉及一种5-酰胺基-2-羟基苯磺酰胺衍生物，其通式表示为：其中，R1是可选取的取代的低烷基，可选取的取代的低烷氧基，可选取的取代的低烯基，环烷基或低酰基等；Q是氢原子或可选取的取代的低烷基；Z是氢原子或羟基等，或其药学上可接受的盐。该衍生物具有强效和选择性的激活血凝因子X抑制活性，可用作预防或治疗与激活血凝因子X相关的疾病的药物，以及包含该衍生物和其中间体的制药组合物。这些化合物可用作各种疾病的预防或治疗，例如脑梗死、脑血栓形成、脑栓塞、短暂性脑缺血发作、脑血管抽搐、阿尔茨海默病、心肌梗死、心脏病发作、心力衰竭、血栓形成、肺梗死和肺栓塞。
• Preparation of 2-chloropropionic acid esters
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0163435A2

  公开（公告）日：1985-12-04

  Racemic and optically active alkyl 2-chloropropionates are prepared by reacting the corresponding alkyl lactates with phosgene and decomposing the chloroformates so obtained in the presence of a tertiary base, preferably pyridine. Conveniently, reaction is carried out in a solvent, eg. dichloromethane. The process is particularly useful for preparing optically active alkyl 2-propionates of high purity in which case the chloroformate intermediates, certain of which are novel, are decomposed at a temperature below 60°C, preferably in the range of 20 to 40'C.

  外消旋光学活性 2-氯丙酸烷基酯的制备方法是：将相应的乳酸烷基酯与光气反应， 然后在三级碱（最好是吡啶）存在下分解所得到的氯甲酸酯。反应宜在溶剂（如二氯甲烷）中进行。该工艺特别适用于制备高纯度的光学活性 2-丙酸烷基酯，在这种情况下，氯甲酸 酯中间体（其中某些是新型的）的分解温度低于 60°C，最好在 20 至 40'C 之间。
• 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1443041A1

  公开（公告）日：2004-08-04

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.

  本发明涉及由通式表示的 5-脒基-2-羟基苯磺酰胺衍生物： 其中 R1 是任选取代的低级烷基、任选取代的低级烷氧基、任选取代的低级烯基、环烷基或低级酰基等； Q 是氢原子或任选取代的低级烷基；以及 Z 是氢原子或羟基等、 或其药学上可接受的盐，它们具有强效和选择性的活化血液凝固因子 X 抑制活性，可用作预防或治疗与活化血液凝固因子 X 有关的疾病的药物、由其组成的药物组合物及其中间体。这些化合物可用于预防或治疗各种疾病，如脑梗塞、脑血栓、脑栓塞、TIA、脑血管痉挛、老年痴呆症、心肌梗塞、心脏病、心力衰竭、血栓形成、肺梗塞和肺栓塞。
• CROSBY, J.
  作者：CROSBY, J.

  DOI：——

  日期：——