(1S)-1-(2-phenylsulfanylphenyl)ethanamine | 1227795-23-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (1S)-1-(2-phenylsulfanylphenyl)ethanamine
• CAS: 1227795-23-4
• 化学式: C₁₄H₁₅NS
• 分子量: 229.346
• InChiKey: UZVLCDUAPAEAJW-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1S)-1-(2-phenylsulfanylphenyl)ethanamine 、 甲酸乙酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以76%的产率得到(1S)-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine
  参考文献：
  名称：

  Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions

  摘要：

  A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 degrees C could be obtained.

  DOI：

  10.1007/s10562-010-0331-2
• 作为产物：
  描述：

  N-(trimethylsilyl)-1-phenylethylamine 、 二苯二硫醚 在 正丁基锂 作用下， 以 乙醚 为溶剂， 生成 (1S)-1-(2-phenylsulfanylphenyl)ethanamine
  参考文献：
  名称：

  Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions

  摘要：

  A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 degrees C could be obtained.

  DOI：

  10.1007/s10562-010-0331-2

文献信息

• Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions
  作者：Ju-Lan Zeng、Sai-Bo Yu、Zhong Cao、Dao-Wu Yang

  DOI：10.1007/s10562-010-0331-2

  日期：2010.6

  A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 degrees C could be obtained.