Acetylcysteine Zinc | 49793-39-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetylcysteine Zinc
• 英文别名: zinc;(2R)-2-acetamido-3-sulfanylpropanoate
• CAS: 49793-39-7
• 化学式: C10H16N2O6S2Zn
• 分子量: 389.8
• InChiKey: KNVKDNCWDNRTOE-SCGRZTRASA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.66
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• COMPOSITIONS AND METHODS FOR CYTOPROTECTION
  申请人：Basnakian Alexei G.

  公开号：US20090042850A1

  公开（公告）日：2009-02-12

  The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.

  本发明提供了细胞保护的组合物和方法。特别是，它提供了包含至少一个锌离子和至少一个氨硫醇配体的锌螯合物组合物。
• [EN] N-ACETYL L-CYSTEINE CHELATES AND METHODS FOR MAKING AND USING THE SAME<br/>[FR] CHÉLATES DE N-ACÉTYLE L-CYSTÉINE ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：VIVA PHARMACEUTICAL INC

  公开号：WO2014209412A1

  公开（公告）日：2014-12-31

  A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stirring and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.

  一种用于人类的营养补充剂，该补充剂具有一个螯合物，由N-乙酰-L-半胱氨酸配体与金属结合形成一个螯合环。一种制备由N-乙酰-L-半胱氨酸配体和金属组成的螯合物的方法包括以下步骤：在水溶液中溶解一定量的N-乙酰-L-半胱氨酸，向水溶液中加入金属，搅拌和加热水溶液，然后在减压下去除溶剂。一种治疗人类氧化应激、心血管疾病、脑血管疾病、神经退行性疾病、阿尔茨海默病、注意力缺陷多动障碍、躁郁症、精神分裂症、自闭症、痴呆症和艾滋病等的方法，包括向人类施用含有N-乙酰-L-半胱氨酸与金属形成螯合物的有效量的组合物。一种具有金属与N-乙酰-L-半胱氨酸配体螯合的螯合制剂的化合物。
• Clinical applications for various thiol complexes and processes for their synthesis
  申请人：CHRONORX, LLC.

  公开号：US20020151533A1

  公开（公告）日：2002-10-17

  This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these and other related individual or complexed thiol-contributing glutathione predecessors. Clinical uses for these molecules and complexes in the beneficial modification of various physiological conditions and functions associated with aging, chronic glaucoma, diabetes mellitus, insulin resistance, macular degeneration, neurodegenerative diseases and vasoconstriction are described in particular.

  本发明涉及半胱氨酸、N-乙酰半胱氨酸、N-(2-巯基丙酰)甘氨酸和L-2-氧噻唑啉-4-羧酸的某些络合物的合成，以及这些和其他相关的单独或复合硫醇贡献谷胱甘肽前体的营养用途。特别地，描述了这些分子和复合物在有益地改变与衰老、慢性青光眼、糖尿病、胰岛素抵抗、黄斑变性、神经退行性疾病和血管收缩等各种生理条件和功能相关的临床用途。
• Unit dosage forms for the treatment of herpes simplex
  申请人：——

  公开号：US20010031737A1

  公开（公告）日：2001-10-18

  The components of this invention are chosen because of their complementarity for the prevention or treatment of diseases caused by the herpes simplex virus. L-Lysine favorably increases the physiologic immunomodulation necessary for defense against this virus. Zinc improves and maintains a normal immune response. 2-Deoxy-2-D-glucose and heparin sodium alter the surface interaction between the herpes virus and the cell, preventing fusion and infectivity. N-Acetyl-L-cysteine increases glutathione levels thereby creating a thiol redox barrier to the virus at the cell membrane. Quercetin reduces intracellular replication of the herpes virus and viral infectivity. Ascorbate, in concert with copper and D-&agr;-tocopherol, provides an antioxidant defense against the herpes virus, which tends to lose latency during period of oxidative, free radical excess. Selenium and quercetin also participate in reducing various oxidative stresses. Together the components of this invention provide the potential for improved resistance to, improved recovery from, and a decreased frequency of recurrence of herpes simplex virus infection.

  之所以选择本发明的成分，是因为它们在预防或治疗由单纯疱疹病毒引起的疾病方面具有互补性。L -赖氨酸能有效提高防御这种病毒所需的生理性免疫调节。锌能改善和维持正常的免疫反应。2-Deoxy-2-D-glucose 和肝素钠能改变疱疹病毒与细胞之间的表面相互作用，防止融合和感染。N-乙酰-L-半胱氨酸能提高谷胱甘肽的含量，从而在细胞膜上形成一道阻挡病毒的硫醇氧化还原屏障。槲皮素能减少疱疹病毒在细胞内的复制，降低病毒的感染性。抗坏血酸与铜和 D-&agr;-生育酚共同为疱疹病毒提供抗氧化防御，因为疱疹病毒在氧化和自由基过剩期间往往会失去潜伏性。硒和槲皮素也参与减少各种氧化压力。本发明的这些成分合在一起，有可能提高对单纯疱疹病毒感染的抵抗力，改善恢复情况，并降低复发频率。
• Dosage forms useful for modifying conditions and functions associated with hearing loss and/or tinnitus
  申请人：——

  公开号：US20020061870A1

  公开（公告）日：2002-05-23

  The invention defines interdependent biofactors and biomolecules, and clinically useful formulations that are comprised of them. The active agents are demonstrated to be complementary in their physiologic functions especially as these relate to the quenching of free radicals and to the support of endothelial physiology, the reduction of hyperinsulinemia and improvements in vascular health. The active components of the invention are selected for inclusion in precise combinations specifically because they improve these various conditions and physiological functions, and by so doing reduce a variety of risks associated with hearing loss and tinnitus. The resulting enhancement of general systemic vascular health, improvement in local VIII th nerve vascular health, modulation of conditions surrounding blood fluid dynamics, the consequences of hyperinsulinemia, and improvements in free radical defenses, all reduce the potential for cochlear hair cell death and VIII th nerve atrophy, and the hearing loss and possible deafness that accompany them.

  本发明定义了相互依存的生物因子和生物分子，以及由它们组成的临床实用配方。活性成分在生理功能上具有互补性，特别是在淬灭自由基、支持内皮生理机能、降低高胰岛素血症和改善血管健康方面。本发明的活性成分之所以被选入精确的组合中，特别是因为它们能改善这些不同的状况和生理功能，从而降低与听力损失和耳鸣相关的各种风险。由此增强全身血管健康，改善局部 VIII 神经血管健康 神经血管健康、调节血液流体动力学、高胰岛素血症的后果以及改善自由基防御能力，所有这些都能降低耳蜗毛细胞死亡和 VIIIth 神经损伤的可能性。 神经萎缩 神经萎缩的可能性，以及随之而来的听力损失和可能的耳聋。