(R)-7,7'-bis[di(p-methoxyphenyl)phosphino]-1,1'-spirobiindane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-7,7'-bis[di(p-methoxyphenyl)phosphino]-1,1'-spirobiindane
• 英文别名: [4'-Bis(4-methoxyphenyl)phosphanyl-3,3'-spirobi[1,2-dihydroindene]-4-yl]-bis(4-methoxyphenyl)phosphane
• 化学式: C₄₅H₄₂O₄P₂
• 分子量: 708.774
• InChiKey: QGVOSJYSSBIQKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  51
• 可旋转键数：
  10
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [RuCl2(benzene)]2 、 (R)-7,7'-bis[di(p-methoxyphenyl)phosphino]-1,1'-spirobiindane 、 1,2-二苯基乙烷-1,2-二胺 以 N,N-二甲基甲酰胺 为溶剂， 生成 [(((R)-An-SDP)Ru(S,S-1,2-diphenylethylenediamine)Cl2]
  参考文献：
  名称：

  Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones

  摘要：

  Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones.

  DOI：

  10.1021/ja029907i
• 作为产物：
  描述：

  bis(4-methoxyphenyl)phosphine oxide 在 palladium diacetate 、 三氯硅烷 、 N,N-二异丙基乙胺 、 1,4-双(二苯基膦)丁烷 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 生成 (R)-7,7'-bis[di(p-methoxyphenyl)phosphino]-1,1'-spirobiindane
  参考文献：
  名称：

  Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones

  摘要：

  Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones.

  DOI：

  10.1021/ja029907i

文献信息

• Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones
  作者：Jian-Hua Xie、Li-Xin Wang、Yu Fu、Shuo-Fei Zhu、Bao-Min Fan、Hai-Feng Duan、Qi-Lin Zhou

  DOI：10.1021/ja029907i

  日期：2003.4.1

  Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones.