4-carbamoyl-nicotinic acid methyl ester | 24202-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-carbamoyl-nicotinic acid methyl ester
• 英文别名: 4-Carbamoyl-3-carbomethoxypyridin；methyl 4-carbamoylpyridine-3-carboxylate
• CAS: 24202-76-4
• 化学式: C₈H₈N₂O₃
• 分子量: 180.163
• InChiKey: FFISEZHTMLXYBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  82.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-carbamoyl-nicotinic acid methyl ester 在 三氯氧磷 作用下， 反应 12.0h， 以55.5%的产率得到4-氰基吡啶-3-甲酸甲酯
  参考文献：
  名称：

  Koermendy, K.; Kovacs, T.; Ruff, F., Acta Chimica Hungarica, 1983, vol. 112, # 4, p. 487 - 500

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮甲烷 、 4-(氨基羰基)-3-吡啶羧酸 以 甲醇 、 乙醚 为溶剂， 以58.3%的产率得到4-carbamoyl-nicotinic acid methyl ester
  参考文献：
  名称：

  Koermendy, K.; Kovacs, T.; Ruff, F., Acta Chimica Hungarica, 1983, vol. 112, # 4, p. 487 - 500

  摘要：

  DOI：

文献信息

• KOERMENDY, K.;KOVACS, T.;RUFF, F.;KOEVESDI, I., ACTA CHIM. HUNG., 1983, 112, N 4, 487-499
  作者：KOERMENDY, K.、KOVACS, T.、RUFF, F.、KOEVESDI, I.

  DOI：——

  日期：——
• NON-INVASIVE METHOD TO MONITOR MICROCIRCULATION
  申请人：Wheelsbridge AB

  公开号：EP1737339A1

  公开（公告）日：2007-01-03
• NON-INVASIVE SYSTEM TO MONITOR MICROCIRCULATION
  申请人：Wheelsbridge AB

  公开号：EP1737339B1

  公开（公告）日：2009-01-07
• Non-invasive method to monitor microcirculation
  申请人：Nilsson Gert

  公开号：US20070146686A1

  公开（公告）日：2007-06-28

  This invention relates to the non-invasive determination of the degree of vasoactivity in the microcirculation in a tissue caused by a drug, disease, injury normal or pathological regulation. More specifically, the invention relates to a method of determining the influence on microcirculation in living tissue from an irritative agent, drugs, disease, injuries normal or pathological regulation including, illuminating a tissue surface with polarized light, collecting the backscattered light through a polarizing filter, detecting the backscattered and polarized light by a photo-sensitive array, transferring the collected information in digital form to a computing device, separating the collected information into at least two data matrixes, each representing a specific wavelength range and generating an output data matrix by processing corresponding values in at least two data matrixes by an algorithm, wherein each value in said output data matrix represents the amount of influence on the microcirculation in a source point of the tissue. Thereby a representation of the tissue microcirculation is obtained.
• US8208997B2
  申请人：——

  公开号：US8208997B2

  公开（公告）日：2012-06-26