4-phenyl-2H-pyrido [1,2-a]pyrimidine-2-one | 66156-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-phenyl-2H-pyrido [1,2-a]pyrimidine-2-one
• 英文别名: 4-phenyl-2H-pyrido[1,2-a]pyrimidin-2-one；4-phenyl-pyrido[1,2-a]pyrimidin-2-one；4-Phenyl-2H-pyrido<1,2-a>pyrimidin-2-on；4-phenylpyrido[1,2-a]pyrimidin-2-one
• CAS: 66156-19-2
• 化学式: C₁₄H₁₀N₂O
• mdl: MFCD05149434
• 分子量: 222.246
• InChiKey: AHPOSBFUSLSSMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 苯丙炔酸乙酯 以 乙醇 为溶剂， 生成 4-phenyl-2H-pyrido [1,2-a]pyrimidine-2-one
  参考文献：
  名称：

  Synthesis of 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-ones utilizing activated alkynoates

  摘要：

  The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluoromethyl substituted pyrido[1,2-a]pyrimidines under mild conditions. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00700-7

文献信息

• Metal and Solvent-Free Synthesis of 2<i>H</i>-Pyrido[1,2-<i>a</i>]pyrimidin-2-ones Catalyzed by Elemental Sulfur
  作者：Thangavel Pavithra、E. Sankari Devi、Subbiah Nagarajan、Vellaisamy Sridharan、C. Uma Maheswari

  DOI：10.1002/ejoc.201901356

  日期：2019.10.31

  method for the synthesis of 4‐methyl‐2H‐pyrido[1,2‐a]pyrimidin‐2‐one from β‐oxo esters and 2‐aminopyridine in the presence of sulfur was demonstrated. In this reaction, inexpensive and readily available starting materials and catalysts were employed. The advantages of this strategy are: (i) A neat, oxidant and metal free reaction. (ii) The reaction was tolerant to different β‐oxo esters and 2‐aminopyridines

  展示了一种在硫存在下由β-氧代酯和2-氨基吡啶合成4-甲基-2 H-吡啶并[1,2 - a ]嘧啶-2-酮的简单有效的方法。在该反应中，使用廉价且容易获得的起始原料和催化剂。该策略的优点是：（i）纯净，无氧化剂和无金属的反应。（ii）该反应可耐受不同的β-氧代酯和2-氨基吡啶
• Copper(II)/Iron(III) Co-catalyzed Intermolecular Diamination of Alkynes: Facile Synthesis of Imidazopyridines
  作者：Jing Zeng、Yu Jia Tan、Min Li Leow、Xue-Wei Liu

  DOI：10.1021/ol301858j

  日期：2012.9.7

  A facile synthesis of imidazo[1,2-alpha]pyridines has been achieved by copper(II) and iron(III) co-catalyzed C-N bond formation. This reaction involves an intermolecular oxidative diamination of alkynes with high chemoselectivity and regioselectivity.
• Palazzo; Tamburini, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1911, vol. <5> 20 I, p. 41
  作者：Palazzo、Tamburini

  DOI：——

  日期：——
• Seide, Chemische Berichte, 1925, vol. 58, p. 354
  作者：Seide

  DOI：——

  日期：——
• JPH04188068A
  申请人：——

  公开号：JPH04188068A

  公开（公告）日：1992-07-06