N-(p-tolylthio)-p-benzoquinone imine | 72600-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(p-tolylthio)-p-benzoquinone imine
• 英文别名: N-(4-oxo-cyclohexa-2,5-dienylidene)-toluene-4-sulfenamide；N-(4-Oxo-cyclohexa-2,5-dienyliden)-toluol-4-sulfenamid；4-(4-Methylphenyl)sulfanyliminocyclohexa-2,5-dien-1-one
• CAS: 72600-15-8
• 化学式: C₁₃H₁₁NOS
• 分子量: 229.302
• InChiKey: RXOFIKNXOJOWSK-UHFFFAOYSA-N

物化性质

• 熔点：
  107-109 °C(Solv: ethanol (64-17-5))
• 沸点：
  374.3±52.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(p-tolylthio)-p-benzoquinone imine 在 氯 、 三乙胺 作用下， 以 四氯化碳 为溶剂， 反应 24.0h， 以60%的产率得到
  参考文献：
  名称：

  Kolesnikov, V. T.; Vid, L. V.; Kuz'menko, L. O., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 1738 - 1740

  摘要：

  DOI：
• 作为产物：
  描述：

  对氨基苯酚 在 sodium dichromate 、 乙醚 、 溶剂黄146 作用下， 生成 N-(p-tolylthio)-p-benzoquinone imine
  参考文献：
  名称：

  COMPLICATIONS OF VASCULAR ACCESS: RESULTS OF A EUROPEAN MULTI CENTRE STUDY OF THE EDTNA/ERCA RESEARCH BOARD

  摘要：

  SUMMARYThe pilot project of the Research Board of EDTNA/ERCA handled the management of vascular accesses (VA) in European dialysis centres. In the first part of the study, centre policies related to VA management were investigated. In the second part of the study, individual patients were followed prospectively during one year. This paper reports on several topics of the second part of the project, investigating complications of the VA related to centre, patient characteristics and dialysis techniques. used.Complications most frequently observed were thrombosis, stenosis, infection, bleeding and flow problems. Gradually more infections and flow problems were observed if the centre size and the patients/nurse ratio went up.Complication rate was not significantly influenced by age, gender, renal diagnosis, time on dialysis or medication used by the patient. In contrast, the number of vascular accesses in the past and interventions in the VA before first use resulted in an increased number of complications.Nurses have a key role in the prevention, manipulation and outcome of vascular access related complications.

  DOI：

  10.1111/j.1755-6686.2003.tb00301.x

文献信息

• Physical Properties and Various Reactions of Thionitrites and Related Substances
  作者：Shigeru Oae、K\={o}ichi Shinhama、Ken Fujimori、Yong Hae Kim

  DOI：10.1246/bcsj.53.775

  日期：1980.3

  Several new sulfonyl or sulfonyl derivativives, thionitrates (RSNO2), sulfonyl nitrites (RSO2NO), were successfully isolated by treating corresponding thiols and sulfinic acids with dinitrogen tetraoxide (N2O4). Spectroscopic data of both stable and many rather unstable compounds were determined and compared with those of corresponding alkyl nitrites (RONO) or alkyl nitrates (RONO2). Chemical reactivities

  通过用四氧化二氮 (N2O4) 处理相应的硫醇和亚磺酸，成功分离了几种新的磺酰基或磺酰基衍生物，即亚硝酸盐 (RSNO2)、亚硝酸磺酰 (RSO2NO)。测定了稳定和许多相当不稳定的化合物的光谱数据，并与相应的亚硝酸烷基酯 (RONO) 或硝酸烷基酯 (RONO2) 的光谱数据进行了比较。研究了这些罕见的新型 S-亚硝基和 S-硝基化合物的化学反应性。
• REACTIONS OF<i>t</i>-ALKYL THIONITRATES WITH<i>p</i>-AMINOPHENOLS: ONE POT SYNTHESES OF<i>N</i>-(<i>t</i>-ALKYLTHIO)-<i>p</i>-BENZOQUINONEIMINES
  作者：Shigeru Oae、Koichi Shinhama、Yong Hae Kim

  DOI：10.1246/cl.1979.1077

  日期：1979.9.5

  Various N-(alkylthio)-p-benzoquinoneimines were readily synthesized by treating corresponding p-aminophenols with t-alkyl thionitrates.

  多种N-(烷基硫)对苯醌亚胺通过将相应的对氨基酚与叔烷基硫氰酸酯反应简单合成。
• Reaction of N-chloro-1,4-benzoquinone imines with thiols
  作者：S. A. Konovalova、A. P. Avdeenko、A. A. Santalova、E. N. Lysenko、K. S. Burmistrov

  DOI：10.1134/s1070428016090062

  日期：2016.9

  N-Chloro-1,4-benzoquinone imines reacted with arenethiols to give different products, depending on the conditions and initial quinone imine structure. N-(Arylsulfanyl)-1,4-benzoquinone imines were obtained as a result of nucleophilic substitution of the chlorine atom, and 1,4-benzoquinone imines containing an aryl-sulfanyl substituent in the quinoid ring were formed according to the radical mechanism. The reactions of N-chloro-1,4-benzoquinone imines with heterocyclic thiols afforded only the corresponding chlorine substitution products.
• Zur Kenntnis der organischen Schwefel-Stickstoff-Bindung
  作者：Rudolf Pollak、Eugen Riesz、Josef Riesz

  DOI：10.1007/bf01532303

  日期：1931.12
• OAE SHIGERU; SHINHAMA KOICHI; KIM YONG HAE, CHEM. LETT., 1979, NO 9, 1077-1080
  作者：OAE SHIGERU、 SHINHAMA KOICHI、 KIM YONG HAE

  DOI：——

  日期：——