The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and pharmaceutical composition comprising the compound of formula (I). The present composition also relates to methods treating a disease or disorder associated with ubiquitin-specific protease 28 (USP28), methods of treating cancer, and methods of inhibiting USP28.
本公开涉及式(I)的化合物或其药用可接受盐,以及包含该式(I)化合物的药物组合物。本组合物还涉及治疗与泛素特异性
蛋白酶28(U
SP28)相关的疾病或紊乱的方法,治疗癌症的方法,以及抑制U
SP28的方法。