propene-1,2,3-tricarboxamide | 63467-46-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: propene-1,2,3-tricarboxamide
• 英文别名: Propen-1,2,3-tricarbamid；(Z)-prop-1-ene-1,2,3-tricarboxamide
• CAS: 63467-46-9
• 化学式: C₆H₉N₃O₃
• 分子量: 171.156
• InChiKey: RXZQNZROTOXEFG-IWQZZHSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 、 水 作用下， 生成 propene-1,2,3-tricarboxamide 、 citrazinic acid
  参考文献：
  名称：

  Hotter, Chemische Berichte, 1889, vol. 22, p. 1078

  摘要：

  DOI：

文献信息

• [EN] A PROCESS FOR THE PREPARTION OF NON-VIRAL VECTOR FOR DELIVERY OF NUCLEIC ACIDS BY MUCOSAL ROUTE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN VECTEUR NON VIRAL POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES PAR VOIE MUQUEUSE
  申请人：DEPT OF BIOTECHNOLOGY INDIA

  公开号：WO2014064710A1

  公开（公告）日：2014-05-01

  The invention relates to a process for preparation of non-viral vector for delivery of nucleic acids by mucosal route comprising the steps' of (a) synthesis of pDNA loaded calcium phosphate nanoparticles using reverse micro-emulsion method having n- Hexane as oil phase and water as the aqueous phase; (b) addition of excess water to make total volume of water to adjust the molar ratio of water to AOT at 10 before stirriung both the micro-emulsions; (c) taking 1.36M of anhydrous calcium chloride and 0.35 M di-sodium hydrogen phosphate in two separate micro-emulsion system as the precursors; (d) adding 3μg of pDNA of interested into each system followed by continuous stirring for 12 hours; (e) mixing the micro- emulsion with di-sodium hydrogen phosphate to the micro-emulsion with calcium chloride at slow rate with continuous stirring at 4°C; (f) keeping the mixture, as obtained in step (e), undisturbed at low temperature under continuous stirring for 24 hours; (g) removing n- Hexane by using Bucci-evaporator and dissolving the resulting mass of AOT in 10 ml of absolute ethanol (99.9%) by vortexing; (h) centrifuging the solution for half an hour at 800 rpm at 4°C in a cold centrifuge; (i) washing the pelleted nanoparticles with absolute alcohol three times; (j) dispersing the pelleted nanoparticles in double distilled water at 4°C by vortexing to secure clear dispersion; and (k) dialyzing the dispersion, as obtained in step (j), in cold room using 14 kD dialysis membrane bag and followed finally for coating over nanoparticles with the polymers.