(E)-4-(4-phenoxyphenoxy)but-2-enoic acid ethyl ester | 370064-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-4-(4-phenoxyphenoxy)but-2-enoic acid ethyl ester
• 英文别名: ethyl (E)-4-(4-phenoxyphenoxy)but-2-enoate
• CAS: 370064-79-2
• 化学式: C₁₈H₁₈O₄
• 分子量: 298.339
• InChiKey: UZRJCROAMGSVFI-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-4-(4-phenoxyphenoxy)but-2-enoic acid ethyl ester 在 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 48.0h， 以59%的产率得到(E)-4-(4-phenoxyphenoxy)but-2-enoic acid
  参考文献：
  名称：

  Design and synthesis of MMP inhibitors using N -arylsulfonylaziridine hydroxamic acids as constrained scaffolds

  摘要：

  The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00641-x
• 作为产物：
  描述：

  4-溴巴豆酸乙酯 、 4-苯氧基苯酚 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以74%的产率得到(E)-4-(4-phenoxyphenoxy)but-2-enoic acid ethyl ester
  参考文献：
  名称：

  Design and synthesis of MMP inhibitors using N -arylsulfonylaziridine hydroxamic acids as constrained scaffolds

  摘要：

  The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00641-x

文献信息

• Design and synthesis of MMP inhibitors using N -arylsulfonylaziridine hydroxamic acids as constrained scaffolds
  作者：Stephen Hanessian、Nicolas Moitessier、Louis-David Cantin

  DOI：10.1016/s0040-4020(01)00641-x

  日期：2001.8

  The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discussed in the context of modeling studies. (C) 2001 Elsevier Science Ltd. All rights reserved.