[2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-[2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-hydroxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl]oxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl] 2,4,6-trichlorobenzoate | 1026299-04-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-[2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-hydroxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl]oxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl] 2,4,6-trichlorobenzoate
• CAS: 1026299-04-6
• 化学式: C₆₇H₈₃Cl₃O₁₀Si₂
• 分子量: 1210.92
• InChiKey: KQNREQRQNLIATL-OZXYZUBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.95
• 重原子数：
  82
• 可旋转键数：
  25
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-[2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-hydroxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl]oxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl] 2,4,6-trichlorobenzoate 在 4-二甲氨基吡啶 、 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 13.0h， 生成 (1S,5S,7S,9S,10R,11S,15S,17S,19S,20R)-9,19-Dihydroxy-10,20-dimethyl-5,15-bis-((1R,2R)-2-methyl-cyclopropyl)-4,14,21,22-tetraoxa-tricyclo[15.3.1.1^7,11]docosane-3,13-dione
  参考文献：
  名称：

  Total synthesis of (−)-clavosolide A

  摘要：

  The total synthesis of (-)-clavosolide A is achieved employing a radical-mediated route to build the substituted tetrahydropyran unit, a Yamaguchi reaction to construct the diolide aglycon and the Schmidt method for the final glycosidation step. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.08.055
• 作为产物：
  描述：

  2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-[2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-hydroxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl]oxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetic acid 、 2,4,6-三氯苯甲酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 [2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-[2-[(2S,3S,4S,6R)-4-[tert-butyl(diphenyl)silyl]oxy-6-[(2S)-2-hydroxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl]oxy-2-[(1R,2R)-2-methylcyclopropyl]ethyl]-3-methyloxan-2-yl]acetyl] 2,4,6-trichlorobenzoate
  参考文献：
  名称：

  Total synthesis of (−)-clavosolide A

  摘要：

  The total synthesis of (-)-clavosolide A is achieved employing a radical-mediated route to build the substituted tetrahydropyran unit, a Yamaguchi reaction to construct the diolide aglycon and the Schmidt method for the final glycosidation step. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.08.055

文献信息

• Total synthesis of (−)-clavosolide A
  作者：Tushar Kanti Chakraborty、Vakiti Ramkrishna Reddy、Amit Kumar Chattopadhyay

  DOI：10.1016/j.tetlet.2006.08.055

  日期：2006.10

  The total synthesis of (-)-clavosolide A is achieved employing a radical-mediated route to build the substituted tetrahydropyran unit, a Yamaguchi reaction to construct the diolide aglycon and the Schmidt method for the final glycosidation step. (c) 2006 Elsevier Ltd. All rights reserved.