1-(4-methylphenyl)-N-propylethanimine | 173974-83-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-methylphenyl)-N-propylethanimine
• CAS: 173974-83-9
• 化学式: C₁₂H₁₇N
• 分子量: 175.274
• InChiKey: LJXATPQEZSTWEP-UHFFFAOYSA-N

物化性质

• 沸点：
  240.0±23.0 °C(Predicted)
• 密度：
  0.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-methylphenyl)-N-propylethanimine 在 盐酸 、 sodium carbonate 、 N-fluorobis<(trifluoromethyl)sulfonyl>imide 作用下， 生成 2,2-二氟-1-(4-甲基苯基)-乙酮
  参考文献：
  名称：

  N-fluoro-bis[(trifluoromethyl)sulfonyl]imide: Electrophilic fluorination of imines and some methyl-substituted pyridines

  摘要：

  Direct fluorination of imines with N-fluoro-bis[(trifluoromethyl)sulfonyl]imide 1 afforded mono and/or difluoroketones without the need of a strong base to first generate the imine anions. Structurally related 2- and 4- methyl-substituted pyridines gave the respective fluoromethyl pyridines with 1. Our results suggest that an enamine intermediate plays a key role in these reactions.

  DOI：

  10.1016/0040-4020(95)00884-b
• 作为产物：
  描述：

  正丙胺 、 对甲基苯乙酮 在 zinc(II) chloride 作用下， 生成 1-(4-methylphenyl)-N-propylethanimine
  参考文献：
  名称：

  N-fluoro-bis[(trifluoromethyl)sulfonyl]imide: Electrophilic fluorination of imines and some methyl-substituted pyridines

  摘要：

  Direct fluorination of imines with N-fluoro-bis[(trifluoromethyl)sulfonyl]imide 1 afforded mono and/or difluoroketones without the need of a strong base to first generate the imine anions. Structurally related 2- and 4- methyl-substituted pyridines gave the respective fluoromethyl pyridines with 1. Our results suggest that an enamine intermediate plays a key role in these reactions.

  DOI：

  10.1016/0040-4020(95)00884-b

文献信息

• N-fluoro-bis[(trifluoromethyl)sulfonyl]imide: Electrophilic fluorination of imines and some methyl-substituted pyridines
  作者：Weiwen Ying、Darryl D. DesMarteau、Yoshihiko Gotoh

  DOI：10.1016/0040-4020(95)00884-b

  日期：1996.1

  Direct fluorination of imines with N-fluoro-bis[(trifluoromethyl)sulfonyl]imide 1 afforded mono and/or difluoroketones without the need of a strong base to first generate the imine anions. Structurally related 2- and 4- methyl-substituted pyridines gave the respective fluoromethyl pyridines with 1. Our results suggest that an enamine intermediate plays a key role in these reactions.