(6-amino-hexyl)-dithiocarbamic acid | 51250-17-0

• 分子结构分类: 有机化合物 - 有机硫化合物
• 英文名称: (6-amino-hexyl)-dithiocarbamic acid
• 英文别名: (6-Amino-hexyl)-dithiocarbamidsaeure；6-aminohexyl-dithiocarbamic acid；NoName_834；6-aminohexylcarbamodithioic acid
• CAS: 51250-17-0
• 化学式: C₇H₁₆N₂S₂
• 分子量: 192.349
• InChiKey: MJENELJXOUHVBB-UHFFFAOYSA-N

物化性质

• 熔点：
  134 °C(Solv: methanol (67-56-1))
• 沸点：
  285.5±42.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  71.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二硫化碳 、 1,6-己二胺 在 甲醇 作用下， 生成 (6-amino-hexyl)-dithiocarbamic acid
  参考文献：
  名称：

  Clinical Characteristics and Six-Month Outcomes of Nursing Home Residents With Low Activities of Daily Living Dependency

  摘要：

  Background. Up to 30% of nursing home residents have very little dependency in activities of daily living (ADLs). We compared the characteristics and six-month outcomes of a sample of low-ADL-dependent nursing home residents (LDR) with other residents.Methods. This is a cross-sectional, six-month follow-up study using secondary data analysis. We combined the separate 1990 and 1993 cohorts in the Resident Assessment Instrument evaluation study. In each case these data were collected in the same 254 nursing homes in 10 states. We studied residents with a length of stay greater than 60 days and age 65 years and older (N = 3955). We compared the baseline characteristics of LDR (n = 985) with all other residents. We then compared six-month outcomes of LDR with other residents and characteristics of LDR with poor outcomes (death or worsened ADL disability) with LDR who remained stable.Results. The LDR had a significantly decreased frequency of geriatric syndromes (i.e., cognitive impairment, urinary incontinence, under-nutrition, vision problems, poor balance, and pressure ulcers) and neurological disease but had the same frequency of non-neurological chronic diseases and were on more medications. Thirty-one percent had poor six-month outcomes associated with baseline poor cognition, incontinence, poor appetite, and presence of vascular disease, daily pain, shortness of breath, and multiple medications.Conclusion. Our research identified 29% of nursing home residents with higher physical function (LDR) who had fewer geriatric syndromes and neurological disease diagnoses; 69% of these remained stable at 6 months. Those LDR with a higher risk of poor outcomes could be prospectively identified. LDR who remained stable for 6 months may represent a group who could potentially be maintained in the community.

  DOI：

  10.1093/gerona/56.5.m292

文献信息

• DE763279
  申请人：——

  公开号：——

  公开（公告）日：——
• Oda et al., Rikagaku Kenkyusho Iho, vol. 19, p. 1466
  作者：Oda et al.

  DOI：——

  日期：——
• Method for producing film-forming diamine-carbon disulphide condensation products
  申请人：RUDOLF KERN

  公开号：US02356764A1

  公开（公告）日：1944-08-29
• Polydithiocarbamate resin
  申请人：Akzo Nobel N.V.

  公开号：EP1302493B1

  公开（公告）日：2009-07-29
• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.