2-oxo-4-(4'-chlorophenyl)-3-ethoxycarbonylpyrrolidine | 28311-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-oxo-4-(4'-chlorophenyl)-3-ethoxycarbonylpyrrolidine
• 英文别名: Ethyl 4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylate
• CAS: 28311-30-0
• 化学式: C₁₃H₁₄ClNO₃
• 分子量: 267.712
• InChiKey: XZLYKHFRQYRZRQ-UHFFFAOYSA-N

物化性质

• 沸点：
  443.5±45.0 °C(Predicted)
• 密度：
  1.265±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  diethyl 2-(1-(4-chlorophenyl)-2-nitroethyl)malonate 在 氯化铵 、 锌 作用下， 以 水 为溶剂， 以78%的产率得到2-oxo-4-(4'-chlorophenyl)-3-ethoxycarbonylpyrrolidine
  参考文献：
  名称：

  Jayapradha; Muthusubramanian, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007, vol. 46, # 10, p. 1645 - 1647

  摘要：

  DOI：

文献信息

• Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid
  申请人：Yasuoka Junichi

  公开号：US20090137819A1

  公开（公告）日：2009-05-28

  The present invention provides a method of producing a compound (IIa) or a compound (IIb), provides a method of producing a compound (IIIa) or a compound (IIIb), provides a method of producing a compound (Va) or its salt or a compound (Vb) or its salt, provides a method of producing a compound (IIIa) or a compound (IIIb), further, provides a method of producing a compound (Va) or its salt or a compound (Vb) or its salt including these production methods.

  本发明提供了生产化合物（IIa）或化合物（IIb）的方法，提供了生产化合物（IIIa）或化合物（IIIb）的方法，提供了生产化合物（Va）或其盐或化合物（Vb）或其盐的方法，提供了生产化合物（IIIa）或化合物（IIIb）的方法，此外，还提供了生产化合物（Va）或其盐或化合物（Vb）或其盐的方法，包括这些生产方法。
• BIFUNCTIONAL CHIRAL ORGANOCATALYTIC COMPOUND HAVING EXCELLENT ENANTIOSELECTIVITY, PREPARATION METHOD THEREFOR, AND METHOD FOR PRODUCING NON-NATURAL GAMMA-AMINO ACID FROM NITRO COMPOUND BY USING SAME
  申请人：KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

  公开号：US20200406243A1

  公开（公告）日：2020-12-31

  The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using the chiral organocatalytic compound. According to the present invention, the bifunctional chiral organocatalytic compound having excellent enantioselectivity can be easily synthesized, gamma-amino acids with high optical selectivity can be obtained at a high yield by an economical and convenient method using the chiral organocatalytic compound, and various (R)-configuration gamma-amino acids, which are not present in nature, can be produced with high optical purity in large quantities by using a small amount of a catalyst, and therefore, the present invention can be widely utilized in various industrial fields including the pharmaceutical industry.
• US8293926B2
  申请人：——

  公开号：US8293926B2

  公开（公告）日：2012-10-23
• Jayapradha; Muthusubramanian, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007, vol. 46, # 10, p. 1645 - 1647
  作者：Jayapradha、Muthusubramanian

  DOI：——

  日期：——