Glycine, N-[4-[(phenylsulfonyl)amino]benzoyl]- | 105959-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Glycine, N-[4-[(phenylsulfonyl)amino]benzoyl]-
• 英文别名: 2-[[4-(benzenesulfonamido)benzoyl]amino]acetic acid
• CAS: 105959-34-0
• 化学式: C₁₅H₁₄N₂O₅S
• 分子量: 334.353
• InChiKey: WUUGZCZCPXWYFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Glycine, N-[4-[(phenylsulfonyl)amino]benzoyl]- 在 sodium acetate 、 氯甲酸乙酯 、 溶剂黄146 、 三乙胺 作用下， 反应 3.5h， 生成 Benzenesulfonic acid 4-[2-(4-benzenesulfonylamino-phenyl)-5-oxo-1-[4-(pyridin-2-ylsulfamoyl)-phenyl]-1,5-dihydro-imidazol-(4Z)-ylidenemethyl]-phenyl ester
  参考文献：
  名称：

  Hanna, M. A.; Girges, M. M.; Berghot, M. A., Phosphorus, Sulfur and Silicon and the Related Elements, 1991, vol. 61, # 3.4, p. 239 - 246

  摘要：

  DOI：

文献信息

• Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
  申请人：Nastech Pharmaceutical Company Inc.

  公开号：US20040157777A1

  公开（公告）日：2004-08-12

  Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.

  描述了包含至少一种Y2受体结合肽（如肽YY（PYY）、神经肽Y（NPY）或胰岛素肽（PP））和一种或多种黏膜传递增强剂的药物组合物和方法，以增强肽YY在鼻黏膜中的传递，用于治疗哺乳动物主体中的多种疾病和病况，包括肥胖。
• Oral drug delivery compositions and methods
  申请人：Emisphere Technologies, Inc.

  公开号：US20030012817A1

  公开（公告）日：2003-01-16

  The present invention relates to an oral drug delivery system, and in particular to modified amino acids and modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acids and derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. Modified amino acids can also form drug containing microspheres. These mixtures are suitable for oral administration of biologically active agents to animals. Methods for the preparation of such amino acids are also disclosed.

  本发明涉及一种口服药物输送系统，具体涉及用于作为敏感剂的生物活性肽的传递系统的修饰氨基酸和修饰氨基酸衍生物。修饰氨基酸和衍生物可以与活性生物制剂形成非共价混合物，并且在另一实施例中可以释放携带活性剂。修饰氨基酸还可以形成含药微球。这些混合物适用于将生物活性剂口服给动物。还公开了制备这种氨基酸的方法。
• Compositions for the delivery of antigens
  申请人：Emisphere Technologies, Inc.

  公开号：US20020001591A1

  公开（公告）日：2002-01-03

  The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.

  本发明涉及用于口服给药抗原的组合物和方法。将抗原和佐剂与酰化氨基酸或多氨基酸，磺化氨基酸或多氨基酸，或其盐结合。
• COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PYY PEPTIDE
  申请人：Quay C. Steven

  公开号：US20070129299A1

  公开（公告）日：2007-06-07

  Pharmaceutical compositions are described comprising PYY(3-36) (SEQ ID NO: 2), a solubilizing agent, a lipid, a polyol.

  本文描述了一种药物组合物，其中包含PYY(3-36) (序列ID号：2)，一种溶解剂，一种脂质和一种多元醇。
• A DEVICE FOR ENHANCED EPITHELIAL PERMEATION OF Y2 RECEPTOR-BINDING PEPTIDES
  申请人：Quay C. Steven

  公开号：US20070161563A1

  公开（公告）日：2007-07-12

  A pharmaceutical device comprising a composition comprising an aqueous solution of PYY(3-36), a cyclodextrin, and a compound selected from phosphatidylcholine or diglyceride, wherein the cyclodextrin and the compound selected from phosphatidylcholine or diglyceride are present in an amount sufficient to enhance epithelial permeation, and wherein the composition is present in a container; and an actuator fluidly connected to the container, wherein the actuator has a tip which defines a passage through which the solution is ejected to produce a spray of the solution.

  一种药物器具，包括一种组合物，该组合物包括PYY（3-36）的水溶液、环糊精和从磷脂酰胆碱或二甘酸选择的化合物，其中环糊精和从磷脂酰胆碱或二甘酸选择的化合物的含量足以增强上皮渗透，且该组合物存在于容器中；以及与容器流体连接的作动器，其中作动器具有一个尖端，其定义了一个通道，通过该通道喷射出解液以产生解液喷雾。