1,4-dihydro-2-[[(4-methoxyphenyl)methyl]oxy]-6-methyl-4-[2-methoxy-6-pentadecylphenyl]-5-pyrimidinecarboxylic acid methyl ester | 637009-81-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,4-dihydro-2-[[(4-methoxyphenyl)methyl]oxy]-6-methyl-4-[2-methoxy-6-pentadecylphenyl]-5-pyrimidinecarboxylic acid methyl ester
• 英文别名: Methyl 4-(2-methoxy-6-pentadecylphenyl)-2-[(4-methoxyphenyl)methoxy]-6-methyl-1,4-dihydropyrimidine-5-carboxylate
• CAS: 637009-81-5
• 化学式: C₃₇H₅₄N₂O₅
• 分子量: 606.846
• InChiKey: BDFCKMDUFVFTJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.9
• 重原子数：
  44
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,4-dihydro-2-[[(4-methoxyphenyl)methyl]oxy]-6-methyl-4-[2-methoxy-6-pentadecylphenyl]-5-pyrimidinecarboxylic acid methyl ester 、 氯甲酸乙酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 3,6-dihydro-4-methyl-6-[2-ethoxy-6-pentadecylphenyl]-2-oxo-1,5-(2H)-pyrimidinedicarboxylic acid 1-ethyl 5-methyl diester
  参考文献：
  名称：

  [EN] SUBSTITUTED DIHYDROPYRIMIDINES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS
  [FR] INHIBITEURS DES CANAUX CALCIQUES À BASE DE DIHYDROPYRIMIDINES, DIHYDROPYRIMIDONES ET DIHYDROPYRIMIDINETHIONES SUBSTITUÉS

  摘要：

  公开号：

  WO2003105854A3

文献信息

• Substituted dihydropyrimidines, dihydropyrimidones and dihydropyrimidinethiones as calcuim channel blockers
  申请人：——

  公开号：US20040058942A1

  公开（公告）日：2004-03-25

  The present invention is directed in part towards methods of modulating the function of calcium channels with pyrimidine-based compounds. In addition, the invention describes methods of preventing and treating calcium channel-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to pyrimidine-based compounds and pharmaceutical compositions comprising these compounds.

  本发明部分涉及使用嘧啶基化合物调节钙通道功能的方法。此外，本发明还描述了使用本发明所确定的化合物预防和治疗有关钙通道的异常状况的方法。此外，本发明涉及嘧啶基化合物和包含这些化合物的药物组合物。
• SUBSTITUTED DIHYDROPYRIMIDINES, DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS
  申请人：Pullela Phani Kumar

  公开号：US20080125449A1

  公开（公告）日：2008-05-29

  The present invention is directed in part towards methods of modulating the function of calcium channels with pyrimidine-based compounds. In addition, the invention describes methods of preventing and treating calcium channel-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to pyrimidine-based compounds and pharmaceutical compositions comprising these compounds.

  本发明部分涉及使用嘧啶类化合物调节钙通道功能的方法。此外，本发明还描述了使用本发明所鉴定的化合物预防和治疗有关钙通道的异常状况的方法。此外，本发明涉及嘧啶类化合物和包含这些化合物的制药组合物。
• SUBSTITUTED DIHYDROPYRIMIDONES AND DIHYDROPYRIMIDINETHIONES AS CALCIUM CHANNEL BLOCKERS
  申请人：VITTAL MALLYA SCIENTIFIC RESEARCH FOUNDATION

  公开号：EP1515723A2

  公开（公告）日：2005-03-23
• CALCIUM CHANNEL BLOCKERS
  申请人：Diakron Pharmaceuticals, Inc.

  公开号：EP1542683A2

  公开（公告）日：2005-06-22
• US7687511B2
  申请人：——

  公开号：US7687511B2

  公开（公告）日：2010-03-30