(S)-2-Amino-4-(dimethylamino)butanoic acid | 777011-50-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-Amino-4-(dimethylamino)butanoic acid
• 英文别名: (2S)-2-amino-4-(dimethylamino)butanoic acid
• CAS: 777011-50-4
• 化学式: C₆H₁₄N₂O₂
• 分子量: 146.19
• InChiKey: XVQRABGSXSUQLJ-YFKPBYRVSA-N

物化性质

• 沸点：
  260.9±30.0 °C(Predicted)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Peptides for Treatment of Obesity
  申请人：Conde-Frieboes Kilian Waldemar

  公开号：US20130012432A1

  公开（公告）日：2013-01-10

  The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

  本发明涉及一种新型肽化合物，其有效调节一个或多个黑色素皮质素受体类型，以及该类化合物在治疗中的应用，包括通过将该类化合物用于需要的患者进行治疗的方法，以及该类化合物在制造药物中的应用。本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或症状方面具有特别的兴趣。
• Peptides for Use in the Treatment of Obesity
  申请人：Sensfuss Ulrich

  公开号：US20100016238A1

  公开（公告）日：2010-01-21

  The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

  本发明涉及一种新型肽化合物，其在调节一种或多种黑素皮质素受体类型方面具有有效性，以及该化合物在治疗中的使用，包括将该化合物用于需要该化合物的患者的治疗方法，以及将该化合物用于制造药物。该发明的化合物在与肥胖相关的多种疾病或病况的治疗方面具有特别的兴趣。
• Novel Peptides for Use in the Treatment of Obesity
  申请人：Sensfuss Ulrich

  公开号：US20100016237A1

  公开（公告）日：2010-01-21

  The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

  本发明涉及一种新型肽化合物，其对一个或多个黑色素皮质素受体类型具有调节作用，以及该化合物在治疗中的应用、包括将该化合物用于治疗需要该化合物的患者的治疗方法，以及将该化合物用于制药的应用。本发明的化合物对于治疗肥胖症以及与肥胖症相关的各种疾病或病况具有特殊的兴趣。
• HEPATITIS C VIRUS INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2049116B1

  公开（公告）日：2012-02-29
• IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2242752B1

  公开（公告）日：2012-08-08