6,8-Dichloro-3-(4-methyl-[1,3]oxazolo[4,5-c]quinolin-2-yl)chromen-2-one | 1042741-13-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6,8-Dichloro-3-(4-methyl-[1,3]oxazolo[4,5-c]quinolin-2-yl)chromen-2-one
• CAS: 1042741-13-8
• 化学式: C₂₀H₁₀Cl₂N₂O₃
• 分子量: 397.217
• InChiKey: BFOJTDTXBPNUEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  65.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-amino-4-hydroxy-2-methyl quinoline 、 6,8-二氯-2-氧代-2H-苯并吡喃-3-羧酸 在 氨基磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.06h， 以83%的产率得到6,8-Dichloro-3-(4-methyl-[1,3]oxazolo[4,5-c]quinolin-2-yl)chromen-2-one
  参考文献：
  名称：

  Sulfamic Acid–Catalyzed One‐Pot Synthesis of 3‐(4,6‐Dimethyl‐oxazolo[4,5‐c]quinolin‐2‐yl)‐chromen‐2‐ones using the Conventional Method and Microwave Irradiation

  摘要：

  A rapid and efficient method for the preparation of 3-(4,6-dimethyl-oxazolo[4,5-c]quinolin-2-yl)-chromen-2-ones by the reaction between 3-amino-2,8-dimethyl-quinolin-4-ol and 2-oxo-2H-chromen-3-carboxylic acid using sulfamic acid as a acid catalyst and dimethyl formamide as a solvent using the conventional method and microwave irradiation is reported.

  DOI：

  10.1080/00397910801991093

文献信息

• Sulfamic Acid–Catalyzed One‐Pot Synthesis of 3‐(4,6‐Dimethyl‐oxazolo[4,5‐c]quinolin‐2‐yl)‐chromen‐2‐ones using the Conventional Method and Microwave Irradiation
  作者：J. Venu Madhav、V. Naveen Kumar、B. Rajitha

  DOI：10.1080/00397910801991093

  日期：2008.5

  A rapid and efficient method for the preparation of 3-(4,6-dimethyl-oxazolo[4,5-c]quinolin-2-yl)-chromen-2-ones by the reaction between 3-amino-2,8-dimethyl-quinolin-4-ol and 2-oxo-2H-chromen-3-carboxylic acid using sulfamic acid as a acid catalyst and dimethyl formamide as a solvent using the conventional method and microwave irradiation is reported.