1-acetyl-2-(2,2-diphenyl-ethyl)-4,5-dihydro-1H-imidazole | 66342-90-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-acetyl-2-(2,2-diphenyl-ethyl)-4,5-dihydro-1H-imidazole
• 英文别名: 1-acetyl-2-(2,2-diphenylethyl)-4,5-dihydro-1H-imidazole；1-acetyl-2-(2,2-diphenyl ethyl)-2-imidazoline；1-[2-(2,2-diphenylethyl)-4,5-dihydroimidazol-1-yl]ethanone
• CAS: 66342-90-3
• 化学式: C₁₉H₂₀N₂O
• 分子量: 292.381
• InChiKey: VQSJNHISONXVLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(2,2-diphenyl-ethyl)-4,5-dihydro-1H-imidazole 、 乙酰氯 在 苯 、 水 、 Sodium sulfate-III 、 乙醚 作用下， 以 吡啶 为溶剂， 反应 2.0h， 以to give 1-acetyl-2-(2,2-diphenyl ethyl)-2-imidazoline having a melting point of 104°-106° C.的产率得到1-acetyl-2-(2,2-diphenyl-ethyl)-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  Treatment of diabetes with 2-substituted-1,3-diazacyclic compounds

  摘要：

  式子为：##STR1## 其中，R.sub.1代表氢原子、卤素原子、低碳基或低氧基基团；R.sub.2代表氢原子、低烷氧羰基基团、脂肪族酰基基团或芳香族酰基基团，其芳香环可能具有来自卤素原子、低碳基、低氧基、酰基和酰氧基的一种或多种取代基；R.sub.3代表氢原子、低碳基、低羟基烷基或芳基烷基；R.sub.4代表氢原子、低碳基或芳基；R.sub.6代表环己基、吡啶基或苯基，其可能具有来自卤素原子、低碳基和低氧基的取代基；A代表-N.dbd.、-N（低碳基）-基团或亚甲基基团；n代表2至4的整数，点线表示双键是可选的；这些衍生物的盐；以及制备这些化合物及其盐的方法；这些化合物及其盐在人类和动物中具有明显的抗糖尿病活性。

  公开号：

  US04136188A1

文献信息

• Oral hypoglycaemic agents
  申请人：——

  公开号：US20020132812A1

  公开（公告）日：2002-09-19

  Compounds of formula (I) which are optionally substituted 2-(&ohgr;,&ohgr;-diarylalkyl)-4,5-dihydro-1H-imidazoles and 2-(&ohgr;,&ohgr;-diarylalkyl)-1,4,5,6-tetrahydropyrimidines and salts thereof with inorganic and organic acids have interesting pharmacological properties. Thus, the compounds are useful in the treatment of type 2 diabetes.

  式(I)的化合物，它们是可选择取代的2-(&ohgr;，&ohgr;-二芳基烷基)-4,5-二氢-1H-咪唑和2-(&ohgr;，&ohgr;-二芳基烷基)-1,4,5,6-四氢嘧啶及其与无机和有机酸的盐具有有趣的药理特性。因此，这些化合物在治疗2型糖尿病方面是有用的。
• US4136188A
  申请人：——

  公开号：US4136188A

  公开（公告）日：1979-01-23
• [EN] 1,3-DIAZAHETEROCYCLIC COMPOUNDS AND THEIR USE AS ORAL HYPOGLYCAEMIC AGENTS<br/>[FR] COMPOSES 1,3 DIAZHETEROCYCLIQUES ET UTILISATION DE CES DERNIERS COMME AGENTS HYPOGLYCEMIANTS
  申请人：NOVO NORDISK AS

  公开号：WO2002038559A1

  公开（公告）日：2002-05-16

  A compound of formula (I) wherein Y is selected from the ring systems (a), (b); R?1 and R2¿ are independently phenyl, naphthyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, quinolyl, 3-4-dihydroquinolyl, 5,6,7,8-tetrahydroquinolyl, isoquinolyl, 3,4-dihydroisoquinolyl, 5,6,7,8-tetrahydroisoquinolyl, indolyl, benzo[b]thienyl, benzimidazozyl, 5,6,7,8-tetrahydroimidazo[1,5-a]pyridyl or benzthiazolyl each of which is optionally substituted. R?3 and R5¿ are independently hydrogen, C¿1-6? alkyl or halogen or when taken together R?3 and R5¿ form an additional bond between the carbon atoms which they are attached; R¿4? is hydrogen, C1-6alkyl, arylC1-6alkyl, C1-6-C(O)- or arylC1-6alkyl-C(O)-, X is -CR?18R19¿- wherein R?18 and R19¿ are independently hydrogen or C¿1-6?alkyl; n is 0, 1 or 2. Thus, the compounds are useful in the treatment of type 2 diabetes.
• Treatment of diabetes with 2-substituted-1,3-diazacyclic compounds
  申请人：Daiichi Seiyaku Co., Ltd.

  公开号：US04136188A1

  公开（公告）日：1979-01-23

  2-SUBSTITUTED-1,3-DIAZACYCLIC COMPOUNDS OF THE FORMULA: ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sub.2 represents a hydrogen atom, a lower alkoxycarbonyl group, an aliphatic acyl group or an aromatic acyl group, the aromatic ring of which may have one or more substituents selected from a halogen atom, a lower alkyl group, a lower alkoxy group, an acyl group and an acyloxy group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or an aralkyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group or an aryl group; R.sub.6 represents a cyclohexyl group, a pyridyl group or a phenyl group which may have a substituent selected from a halogen atom, a lower alkyl group and a lower alkoxy group; A represents -N.dbd., an -N(lower alkyl)- group or a methylene group; n represents an integer of from 2 to 4, and a dotted line indicates that a double bond is optional; salts of such derivatives; and the method for preparing such compounds and their salts; the compounds and their salts having a distinct anti-diabetic activity in humans and animals.

  2-取代-1,3-二氮杂环化合物的化学式如下：##STR1## 其中R.sub.1代表氢原子、卤原子、低碳基或低氧基基团；R.sub.2代表氢原子、低碳氧羰基团、脂肪族酰基团或芳香族酰基团，芳香环可能具有一个或多个取代基，选自卤原子、低碳基、低氧基、酰基和酰氧基；R.sub.3代表氢原子、低碳基、低羟基碳基或芳基碳基；R.sub.4代表氢原子、低碳基或芳基；R.sub.6代表环己基、吡啶基或苯基，可能具有一个取代基，选自卤原子、低碳基和低氧基；A代表-N.dbd.、-N(低碳基)-基团或亚甲基基团；n表示2到4之间的整数，虚线表示双键是可选的；这些衍生物的盐；以及制备这种化合物及其盐的方法；这些化合物及其盐在人类和动物中具有明显的抗糖尿病活性。