2-cyclopropylidene-2-(2-bromo phenyl)-1-phenoxy ethane | 188549-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-cyclopropylidene-2-(2-bromo phenyl)-1-phenoxy ethane
• 英文别名: 1-Bromo-2-(1-cyclopropylidene-2-phenoxyethyl)benzene
• CAS: 188549-22-6
• 化学式: C₁₇H₁₅BrO
• 分子量: 315.209
• InChiKey: PCMOUUBYYMOLTR-UHFFFAOYSA-N

物化性质

• 沸点：
  442.0±33.0 °C(Predicted)
• 密度：
  1.397±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  二甲基丙二酸钠 、 2-cyclopropylidene-2-(2-bromo phenyl)-1-phenoxy ethane 在 palladium diacetate 、 三苯基膦 作用下， 生成 dimethyl-[2-cyclopropylidene-2-(2-bromo phenyl) ethyl] malonate
  参考文献：
  名称：

  Palladium (0) Catalyzed Nucleophilic Substitution On 2-Cyclopropylidene-phenoxy Ethanes

  摘要：

  2-cyclopropylidene-phenoxy ethanes 5, 2-substituted with alkyl, aryl or heterocyclic groups are readily obtained in high yields by the Wittig reaction of the easily accessible a-phenoxy etanones 4 with (3-bromo propyl) triphenylphosphonium bromide. They react with complete regioselectivity in palladium (0) catalyzed nucleophilic substitutions with a series of soft carbon nucleophiles giving an easy entry to 5,6-methanoamino acids.

  DOI：

  10.1080/00397919708004192
• 作为产物：
  描述：

  2-溴-1-(2-溴苯基)乙酮 在 乙醇 、 三(3,6-二氧杂庚基)胺 、 sodium hydride 、 potassium carbonate 作用下， 反应 40.0h， 生成 2-cyclopropylidene-2-(2-bromo phenyl)-1-phenoxy ethane
  参考文献：
  名称：

  Palladium (0) Catalyzed Nucleophilic Substitution On 2-Cyclopropylidene-phenoxy Ethanes

  摘要：

  2-cyclopropylidene-phenoxy ethanes 5, 2-substituted with alkyl, aryl or heterocyclic groups are readily obtained in high yields by the Wittig reaction of the easily accessible a-phenoxy etanones 4 with (3-bromo propyl) triphenylphosphonium bromide. They react with complete regioselectivity in palladium (0) catalyzed nucleophilic substitutions with a series of soft carbon nucleophiles giving an easy entry to 5,6-methanoamino acids.

  DOI：

  10.1080/00397919708004192

文献信息

• Palladium (0) Catalyzed Nucleophilic Substitution On 2-Cyclopropylidene-phenoxy Ethanes
  作者：Angela M. Bernard、Pier P. Piras

  DOI：10.1080/00397919708004192

  日期：1997.3

  2-cyclopropylidene-phenoxy ethanes 5, 2-substituted with alkyl, aryl or heterocyclic groups are readily obtained in high yields by the Wittig reaction of the easily accessible a-phenoxy etanones 4 with (3-bromo propyl) triphenylphosphonium bromide. They react with complete regioselectivity in palladium (0) catalyzed nucleophilic substitutions with a series of soft carbon nucleophiles giving an easy entry to 5,6-methanoamino acids.