2-hydroxymethyl-valeric acid | 128140-14-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxymethyl-valeric acid
• 英文别名: α-Oxy-pentan-β-carbonsaeure；α-Propyl-hydracrylsaeure；2-Hydroxymethyl-valeriansaeure；2-Methylol-pentansaeure-(1)；2-(Hydroxymethyl)pentanoic acid
• CAS: 128140-14-7
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: HPVOTSMEHLZBJY-UHFFFAOYSA-N

物化性质

• 沸点：
  259.6±23.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-valeric acid 在 硫酸 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  乙醋杆菌介导的非手性1,3-二醇的氧化脱对称法合成对映体富集的2-羟甲基链烷酸

  摘要：

  非手性2-烷基-1,3-二醇的立体选择性去对称化是通过醋乙酸醋杆菌MIM 2000/28氧化两个对位伯醇部分之一进行的，以提供相应的手性2-羟甲基链烷酸（最高94 ％ee）。该过程在pH，温度和压力中等的水性介质中进行，有助于扩大有机化学家可用于开发可持续生产工艺的酶促氧化反应的范围。

  DOI：

  10.1002/cctc.201601051
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 在 锌 、 苯 作用下， 生成 2-hydroxymethyl-valeric acid
  参考文献：
  名称：

  Blaise; Luttringer, Bulletin de la Societe Chimique de France, 1905, vol. <3>33, p. 650

  摘要：

  DOI：

文献信息

• EFTU INHIBITORS OR AMINOTHIAZOLES AND THEIR USES
  申请人：LaMarche Matthew J.

  公开号：US20080221142A1

  公开（公告）日：2008-09-11

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了对治疗、预防和/或改善疾病有用的有机化合物。
• AMINOTHIAZOLES AND THEIR USES
  申请人：Bushell Simon

  公开号：US20140315790A1

  公开（公告）日：2014-10-23

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.

  本申请描述了对治疗、预防和/或改善疾病有用的有机化合物。
• Process for producing polymerizable polybranched polyester
  申请人：Hayakawa Hitoshi

  公开号：US20060047140A1

  公开（公告）日：2006-03-02

  The present invention allows the production of a polymerizable hyperbranched polyester by introducing polymerizable unsaturated double bonds into the molecular terminals of a hyperbranched polyester polyol (A), which is obtained by condensation polymerization a polyhydroxy monocarboxylic acid in which there are at least two hydroxyl groups, the carbon atom adjacent to the carboxy group is saturated carbon atom, and the hydrogen atoms on said carbon atom are all substituted, by reacting the hyperbranched polyester polyol (A) and an alkyl ester of a carboxylic acid having a polymerizable unsaturated double bond (B) by a transesterification in the presence of at least one type of transesterification catalyst (C) selected from the group consisting of a dialkyl tin oxide and a stanoxane, without causing side reactions such as nucleophilic addition reactions of terminal hydroxyl groups to polymerizable unsaturated double bonds of the hyperbranched polyester polyol (A), or thermal polymerization of the polymerizable unsaturated double bonds. The polymerizable hyperbranched polyester can be produced at high efficiency using a transesterification that uses as an alkyl ester of a carboxylic acid having a polymerizable unsaturated double bond (B), which is easily obtained as an industrial raw material, and without altering the original backbone structure of the molecular chains of the hyperbranched polyester polyol (A) by hydrolysis and so forth.

  本发明通过在超支化聚酯多元醇（A）的分子端引入可聚合不饱和双键，从而允许生产可聚合的超支化聚酯。超支化聚酯多元醇（A）是通过缩聚至少含有两个羟基的聚羟基一元羧酸（羧基相邻的碳原子是饱和碳原子，该碳原子上的氢原子均被取代）而获得的。在至少一种转酯化催化剂（C）的存在下，通过将超支化聚酯多元醇（A）和具有可聚合不饱和双键的羧酸烷基酯（B）进行酯交换反应，而不引起末端羟基对超支化聚酯多元醇（A）的可聚合不饱和双键的亲核加成反应或热聚合反应等副反应，就可以高效地生产可聚合的超支化聚酯。使用作为工业原料易于获得的具有可聚合不饱和双键的羧酸烷基酯（B）进行酯交换反应，无需通过水解等改变超支化聚酯多元醇（A）的分子链的原始骨架结构。
• Aqueous-based coating compositions comprising anionic polyurethane principal resin and anionic acrylic grind resin
  申请人：BASF Corporation

  公开号：EP0394737A1

  公开（公告）日：1990-10-31

  Aqueous-based basecoat compositions, useful for application to metal and/or plastic substrates, comprise an anionic polyurethane principal resin and an anionic acrylic pigment grind resin. The compositions are particularly adapted to application to substrates over a wide range of ambient humidities and have quick drying characteristics. The incorporation of an anionic acrylic grind resin, which is compatible with the anionic polyurethane principal resin, produces a coating which has good pigment wetting and dispersion characteristics with improved shelf life and color stability.

  适用于金属和/或塑料底材的水性底漆组合物由阴离子聚氨酯主树脂和阴离子丙烯酸颜料研磨树脂组成。这种组合物特别适合用于环境湿度范围较宽的底材，并具有快速干燥的特点。加入与阴离子聚氨酯主树脂相容的阴离子丙烯酸研磨树脂后，涂料具有良好的颜料润湿和分散特性，并能提高保质期和色彩稳定性。
• Process for the separation of the optical isomers of alpha-substituted carboxylic acids
  申请人：MINISTERO DELL' UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA

  公开号：EP0510712A2

  公开（公告）日：1992-10-28

  A process is described for the separation of the optical isomers of alpha-aryl- or alpha-aryloxy- carboxylic acids by means of the stereoselective hydrolysis of racemic alkyl esters of the above acids in the presence of bacteria or their enzymes, selected from the species Brevibacterium, Bacteridium, Micrococcus, and Bacillus.

  本发明描述了一种分离α-芳基羧酸或α-芳氧基羧酸光学异构体的工艺，其方法是在细菌或其酶的存在下，通过对上述酸的外消旋烷基酯进行立体选择性水解，这些细菌或其酶选自 Brevibacterium、Bacteridium、Micrococcus 和 Bacillus 物种。