(E)-N-(3-nitrobenzylidene)piperidin-1-amine | 1450909-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-(3-nitrobenzylidene)piperidin-1-amine
• 英文别名: N-[(E)-(3-nitrophenyl)methylidene]piperidin-1-amine；(E)-1-(3-nitrophenyl)-N-piperidin-1-ylmethanimine
• CAS: 1450909-00-8
• 化学式: C₁₂H₁₅N₃O₂
• 分子量: 233.27
• InChiKey: CGHOTLVFYRENLN-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间硝基苯甲醛 、 N-氨基哌啶盐酸盐 以 乙醇 为溶剂， 以88%的产率得到(E)-N-(3-nitrobenzylidene)piperidin-1-amine
  参考文献：
  名称：

  Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones

  摘要：

  The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.

  DOI：

  10.1021/ol4020865

文献信息

• Catalytic Asymmetric Construction of Chiral Hydropyridazines <i>via</i> Conjugate Addition of <i>N</i>-Monosubstituted Hydrazones to Enones
  作者：Wenbin Wu、Xiaoqian Yuan、Juan Hu、Xinxin Wu、Yuan Wei、Zunwu Liu、Junzhu Lu、Jinxing Ye

  DOI：10.1021/ol4020865

  日期：2013.9.6

  The first example of a highly enantioselective and scalable formal diaza-ene reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.