(S)-1-(n-butyltellanyl)-2-propanol | 915040-56-1

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: (S)-1-(n-butyltellanyl)-2-propanol
• 英文别名: (2S)-1-butyltellanylpropan-2-ol
• CAS: 915040-56-1
• 化学式: C₇H₁₆OTe
• 分子量: 243.803
• InChiKey: YHZRUZUAQGSFEO-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.71
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (S)-1-(n-butyltellanyl)-2-propanol 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 生成 (1S,2S')-1-methyl-2-(n-butyltellanyl)ethyl 3',3',3'-trifluoro-2'-methoxy-2'-phenylpropionate
  参考文献：
  名称：

  Lipase-catalyzed kinetic resolution of (RS)-hydroxy tellurides

  摘要：

  The enzymatic resolution of racemic mixtures of hydroxy tellurides with a range of lipases has been investigated. Lipase-B from Candida antarctica (CALB) gave the best conversions, providing both enantiomers with high enantiomeric purity. A comparative study of the effect of solvent and substrate on the enzymatic kinetic resolution was performed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.024
• 作为产物：
  描述：

  (RS)-O-acetyl-1-(n-butyltellanyl)-2-propanol 在 Novozym 435(R) 、 potassium carbonate 作用下， 以 甲醇 、 正己烷 、 水 为溶剂， 反应 2.0h， 生成 (S)-1-(n-butyltellanyl)-2-propanol
  参考文献：
  名称：

  Lipase-catalyzed kinetic resolution of (RS)-hydroxy tellurides

  摘要：

  The enzymatic resolution of racemic mixtures of hydroxy tellurides with a range of lipases has been investigated. Lipase-B from Candida antarctica (CALB) gave the best conversions, providing both enantiomers with high enantiomeric purity. A comparative study of the effect of solvent and substrate on the enzymatic kinetic resolution was performed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.024

文献信息

• Lipase-catalyzed kinetic resolution of (RS)-hydroxy tellurides
  作者：Alcindo A. Dos Santos、Carlos E. Da Costa、Jefferson L. Princival、João V. Comasseto

  DOI：10.1016/j.tetasy.2006.07.024

  日期：2006.9

  The enzymatic resolution of racemic mixtures of hydroxy tellurides with a range of lipases has been investigated. Lipase-B from Candida antarctica (CALB) gave the best conversions, providing both enantiomers with high enantiomeric purity. A comparative study of the effect of solvent and substrate on the enzymatic kinetic resolution was performed. (c) 2006 Elsevier Ltd. All rights reserved.