H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Cha-Gly-Leu-Met-NH2 | 79820-90-9

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Cha-Gly-Leu-Met-NH2
• 英文别名: (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
• CAS: 79820-90-9
• 化学式: C₆₃H₁₀₄N₁₈O₁₃S
• 分子量: 1353.7
• InChiKey: GOUPEYQHQVECGS-CUZNLEPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  95
• 可旋转键数：
  42
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  544
• 氢给体数：
  15
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  BOC-甘氨酸 、 BOC-L-亮氨酸 、 Boc-L-蛋氨酸 、 丁氧羰基--环乙基-丙氨酸-羟基盐酸盐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Cha-Gly-Leu-Met-NH2
  参考文献：
  名称：

  Synthesis of peptides by the solid-phase method. 7. Substance P and analogs

  摘要：

  Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the compounds were characterized by thin-layer chromatography, paper electrophoresis, and amino acid and elemental analysis. The biological activities of the peptides were evaluated in vitro on the guinea pig ileum, the rabbit mesenteric vein, and the dog common carotid artery and in vivo on the rat blood pressure. It is shown that the replacement of some residues in the undecapeptide substance P causes variable losses of apparent affinity with a little or no change in the intrinsic activity. All the analogues used in the present study were found to be inactive as antagonists.

  DOI：

  10.1021/jm00343a012

文献信息

• Synthesis of peptides by the solid-phase method. 7. Substance P and analogs
  作者：A. Fournier、R. Couture、D. Regoli、M. Gendreau、S. St-Pierre

  DOI：10.1021/jm00343a012

  日期：1982.1

  Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the compounds were characterized by thin-layer chromatography, paper electrophoresis, and amino acid and elemental analysis. The biological activities of the peptides were evaluated in vitro on the guinea pig ileum, the rabbit mesenteric vein, and the dog common carotid artery and in vivo on the rat blood pressure. It is shown that the replacement of some residues in the undecapeptide substance P causes variable losses of apparent affinity with a little or no change in the intrinsic activity. All the analogues used in the present study were found to be inactive as antagonists.