3-(4-chlorophenylsulfonyl)propanoyl chloride | 932047-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-chlorophenylsulfonyl)propanoyl chloride
• 英文别名: 3-(4-chlorophenyl)sulfonylpropanoyl chloride
• CAS: 932047-87-5
• 化学式: C₉H₈Cl₂O₃S
• 分子量: 267.133
• InChiKey: ZCKZUNVZWIPMMD-UHFFFAOYSA-N

物化性质

• 沸点：
  422.3±45.0 °C(Predicted)
• 密度：
  1.446±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-chlorophenylsulfonyl)propanoyl chloride 在 三氯化铝 作用下， 以 二硫化碳 为溶剂， 反应 3.0h， 以81%的产率得到3-(4-氯苯磺酰基)-丙酸
  参考文献：
  名称：

  Abdel-Wahab, Aboel-Magd A.; El-Khawaga, Ahmed M.; El-Zohry, Maher F., Phosphorus and Sulfur and the Related Elements, 1984, vol. 19, p. 31 - 44

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(4-氯苯磺酰基)-丙酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以100%的产率得到3-(4-chlorophenylsulfonyl)propanoyl chloride
  参考文献：
  名称：

  WO2008/48609

  摘要：

  公开号：

文献信息

• BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
  申请人：Santora Vincent J.

  公开号：US20100240653A1

  公开（公告）日：2010-09-23

  The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.

  本发明涉及公式（Ia）的某些联苯磺酰胺衍生物及其制药组合物，其调节组织胺H3受体的活性。本发明的化合物和制药组合物适用于治疗组织胺H3相关疾病的方法，例如认知障碍，癫痫，脑外伤，抑郁症，肥胖症，睡眠和清醒障碍，如嗜睡症，倒班综合征，药物副作用引起的嗜睡，维持警觉以帮助完成任务等，猝倒症，过度睡眠症，嗜睡综合征，时差反应，睡眠呼吸暂停等，注意力缺陷多动障碍（ADHD），精神分裂症，过敏症，上呼吸道过敏反应，过敏性鼻炎，鼻塞，痴呆，阿尔茨海默病等。
• [EN] BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO<br/>[FR] MODULATEURS BIPHÉNYLSULFONYLE ET DE PHÉNYL-HÉTÉRORARYLSULFONYLE DU RECEPTEUR H3 DE L'HISTAMINE UTILES POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À CELUI-CI
  申请人：ARENA PHARM INC

  公开号：WO2008048609A1

  公开（公告）日：2008-04-24

  [EN] The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3- receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
  [FR] La présente invention concerne certains dérivés biphénylsulfamides selon la formule (Ia) et leurs compositions pharmaceutiques qui modulent l'activité du récepteur H3 de l'histamine. Des composés de la présente invention et leurs compositions pharmaceutiques sont destinés à des procédés utiles dans le traitement de troubles associés au récepteur H3 de l'histamine, tels que des troubles cognitifs, l'épilepsie, les traumatismes crâniens, la dépression, l'obésité, des troubles de la veille et du sommeil tels que la narcolepsie, le syndrome du travail par équipes, l'endormissement en tant qu'effet secondaire d'un médicament, le maintien de la vigilance pour aider à l'accomplissement de tâches et autres activités similaires, la cataplexie, l'hypersomnie, le syndrome de la somnolence, le syndrome du décalage horaire, l'apnée du sommeil et autres conditions similaires, des troubles d'hyperactivité avec déficit d'attention (ADHD), la schizophrénie, les allergies, les réactions allergiques au niveau des voies respiratoires supérieures, la rhinite allergique, la congestion nasale, la démence, la maladie d'Alzheimer et autres maladies similaires.
• INHIBITORS OF RNA-GUIDED NUCLEASES AND USES THEREOF
  申请人：The Brigham and Women's Hospital, Inc.

  公开号：US20240115557A1

  公开（公告）日：2024-04-11

  The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in the demand for inhibitory anti-CRISPR molecules. Current small-molecule inhibitor discovery platforms are not generalizable to multiple nuclease classes, only target the initial step in the catalytic activity, and require high concentration of nuclease, resulting in inhibitors with suboptimal attributes, including poor potency. Herein, Applicants report a high-throughput discovery pipeline consisting of a FRET-based assay that is generalizable to contemporary and emerging nucleases, operates at low nuclease concentration, and targets all catalytic steps. Applicants applied this pipeline to identify BRD7586, a cell-permeable small-molecule inhibitor of SpCas9, that is 2-fold more potent than current inhibitors. Furthermore, unlike the reported inhibitors, BRD7586 enhanced SpCas9 specificity and its activity was independent of the genomic loci, DNA repair pathway, or mode of nuclease delivery. Overall, these studies describe a general pipeline to identify inhibitors of contemporary and emerging CRISPR-associated nucleases. Described herein are compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions.
• Abdel-Wahab, Aboel-Magd A.; El-Khawaga, Ahmed M.; El-Zohry, Maher F., Phosphorus and Sulfur and the Related Elements, 1984, vol. 19, p. 31 - 44
  作者：Abdel-Wahab, Aboel-Magd A.、El-Khawaga, Ahmed M.、El-Zohry, Maher F.、Khalaf, Ali A.

  DOI：——

  日期：——
• WO2008/48609
  申请人：——

  公开号：——

  公开（公告）日：——